Zainab H Al Mubarak1, Rajagopal Ramesh2, Lin Liu3, Sadagopan Krishnan4. 1. Department of Chemistry, Oklahoma State University, Stillwater, OK 74078, United States. 2. Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States. 3. Department of Physiological Sciences, Oklahoma State University, Stillwater, OK 74078, United States. 4. Department of Chemistry, Oklahoma State University, Stillwater, OK 74078, United States. Electronic address: gopan.krishnan@okstate.edu.
Abstract
HYPOTHESIS: We hypothesize that surface plasmon resonance imaging (SPRi) of interactions between small organic compounds and gold is influenced by the refractive index and chemical structures of the compounds. EXPERIMENTS: For the first time we imaged the SPR signals upon interaction of a gold surface with seven compounds representing aromatic, cyclic, short chain, and long chain carbon structures using an array format. FINDINGS: The refractive index and chemical structures of the tested compounds influenced the sensitivity of detection of the SPR microarray imager. Thus, the array methodology presented herein is suitable for studying interactions of small molecules with a gold surface.
HYPOTHESIS: We hypothesize that surface plasmon resonance imaging (SPRi) of interactions between small organic compounds and gold is influenced by the refractive index and chemical structures of the compounds. EXPERIMENTS: For the first time we imaged the SPR signals upon interaction of a gold surface with seven compounds representing aromatic, cyclic, short chain, and long chain carbon structures using an array format. FINDINGS: The refractive index and chemical structures of the tested compounds influenced the sensitivity of detection of the SPR microarray imager. Thus, the array methodology presented herein is suitable for studying interactions of small molecules with a gold surface.
Authors: D L Ashley; M A Bonin; F L Cardinali; J M McCraw; J S Holler; L L Needham; D G Patterson Journal: Anal Chem Date: 1992-05-01 Impact factor: 6.986
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