Marika Salminen1, Pilvi Saaristo2, Maritta Salonoja3, Sari Vaapio4, Tero Vahlberg5, Christel Lamberg-Allardt2, Pertti Aarnio6, Sirkka-Liisa Kivelä7. 1. Institute of Clinical Medicine, Family Medicine, University of Turku, Turku, Finland; Härkätie Health Centre, Lieto, Finland; Primary Health Care Unit, Hospital District of Southwest Finland and Satakunta, Turku and Pori, Finland. Electronic address: majosa@utu.fi. 2. Calcium Research Unit, Department of Food and Environmental Sciences, University of Helsinki, Finland. 3. Pori City Hospital, Pori, Finland. 4. Institute of Clinical Medicine, Family Medicine, University of Turku, Turku, Finland; Primary Health Care Unit, Hospital District of Southwest Finland and Satakunta, Turku and Pori, Finland. 5. Institute of Clinical Medicine, Biostatistics, University of Turku, Turku, Finland. 6. Satakunta Central Hospital, Pori, Finland. 7. Institute of Clinical Medicine, Family Medicine, University of Turku, Turku, Finland; Faculty of Pharmacy, Division of Social Pharmacy, University of Helsinki, Helsinki, Finland.
Abstract
OBJECTIVE: The aim was to describe vitamin D status and its association with changes in PF during 12 months in Finnish community-dwelling elderly (≥65 years). METHODS AND RESULTS: Baseline serum 25-hydroxyvitamin D (25OHD) concentration was measured by enzymeimmunoassay, and participants (n=518) were divided according to 25OHD to three groups (I <50 nmol/l, II 50-74.9 nmol/l, and III ≥75 nmol/l). PF (maximal isometric extension strength of right and left knee, and time in five-repetition sit-to-stand test (5STS) and 10-m walking test) was measured at baseline and after 12 months. 25OHD deficiency (<50 nmol/l) was found in 20.5% of the participants. During a 12-month follow-up, differences in changes in knee extensor strength of right (p=0.044) and left (p=0.010) lower extremity and in 10-m walking test (p=.040) between the groups were significant. According to further pairwise comparisons these differences were between groups I and III (right knee, p=0.036; left knee, p=0.009; 10-m walk, p=0.044), with the exception of left knee extensor strength in which there were also significant difference between groups I and II (p=0.039). All significant differences in changes were in favour of group II or III. Significant differences in changes in knee extensor strengths maintained after adjustments for group (intervention/control), parathyroid hormone, and baseline level of knee extensor strength. CONCLUSIONS: Prospective analyses showed low 25OHD concentrations (<50 nmol/l) to be associated with deterioration in PF during 12 months compared with high 25OHD concentrations (≥75 nmol/l).
OBJECTIVE: The aim was to describe vitamin D status and its association with changes in PF during 12 months in Finnish community-dwelling elderly (≥65 years). METHODS AND RESULTS: Baseline serum 25-hydroxyvitamin D (25OHD) concentration was measured by enzymeimmunoassay, and participants (n=518) were divided according to 25OHD to three groups (I <50 nmol/l, II 50-74.9 nmol/l, and III ≥75 nmol/l). PF (maximal isometric extension strength of right and left knee, and time in five-repetition sit-to-stand test (5STS) and 10-m walking test) was measured at baseline and after 12 months. 25OHD deficiency (<50 nmol/l) was found in 20.5% of the participants. During a 12-month follow-up, differences in changes in knee extensor strength of right (p=0.044) and left (p=0.010) lower extremity and in 10-m walking test (p=.040) between the groups were significant. According to further pairwise comparisons these differences were between groups I and III (right knee, p=0.036; left knee, p=0.009; 10-m walk, p=0.044), with the exception of left knee extensor strength in which there were also significant difference between groups I and II (p=0.039). All significant differences in changes were in favour of group II or III. Significant differences in changes in knee extensor strengths maintained after adjustments for group (intervention/control), parathyroid hormone, and baseline level of knee extensor strength. CONCLUSIONS: Prospective analyses showed low 25OHD concentrations (<50 nmol/l) to be associated with deterioration in PF during 12 months compared with high 25OHD concentrations (≥75 nmol/l).
Authors: Emma L Carson; L Kirsty Pourshahidi; Sharon M Madigan; Francina R Baldrick; Martin G Kelly; Eamon Laird; Martin Healy; J J Strain; Maria S Mulhern Journal: Int J Chron Obstruct Pulmon Dis Date: 2018-08-28
Authors: Hugo J Bello; Alberto Caballero-García; Daniel Pérez-Valdecantos; Enrique Roche; David C Noriega; Alfredo Córdova-Martínez Journal: Nutrients Date: 2021-11-10 Impact factor: 5.717