| Literature DB >> 26321222 |
Xuefeng Wang1, Xin Zhao2, Chao Feng3, Aliyah Weinstein4, Rui Xia5, Wen Wen3, Quansheng Lv3, Shuting Zuo6, Peijun Tang7, Xi Yang8, Xiaojuan Chen9, Hongrui Wang10, Shayang Zang5, Lindsay Stollings11, Timothy L Denning12, Jingting Jiang13, Jie Fan14, Guangbo Zhang15, Xueguang Zhang3, Yibei Zhu3, Walter Storkus4, Binfeng Lu16.
Abstract
Cytokines play a pivotal role in regulating tumor immunogenicity and antitumor immunity. IL-36γ is important for the IL-23/IL-17-dominated inflammation and anti-BCG Th1 immune responses. However, the impact of IL-36γ on tumor immunity is unknown. Here we found that IL-36γ stimulated CD8(+) T cells, NK cells, and γδ T cells synergistically with TCR signaling and/or IL-12. Importantly, IL-36γ exerted profound antitumor effects in vivo and transformed the tumor microenvironment in favor of tumor eradication. Furthermore, IL-36γ strongly increased the efficacy of tumor vaccination. Moreover, IL-36γ expression inversely correlated with the progression of human melanoma and lung cancer. Our study establishes a role of IL-36γ in promoting antitumor immune responses and suggests its potential clinical translation into cancer immunotherapy.Entities:
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Year: 2015 PMID： 26321222 PMCID： PMC4573903 DOI： 10.1016/j.ccell.2015.07.014
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743