Literature DB >> 26320620

New class of 8-aryl-7-deazaguanine cell permeable fluorescent probes.

Ilirian Dhimitruka1, Timothy D Eubank2, Amy C Gross1, Valery V Khramtsov1.   

Abstract

A one step synthesis of fluorescent 8-aryl-(7-deazaguanines) has been accomplished. Probes exhibit blue to green high quantum yield fluorescence in a variety of organic and aqueous solutions, high extinction coefficients, and large Stokes shifts often above 100 nm. The probes are highly cell permeable, and exhibit stable bright fluorescence once intracellular; therefore are suited to the design of biosensors.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  2,4-Diamino-6-hydroxypyrimidine; 8-Aryl-7-deazaguanine; Cellular permeability; Fluorescent probes; Phenacyl bromides

Mesh：

Substances：

Year:  2015        PMID： 26320620      PMCID： PMC4592842          DOI： 10.1016/j.bmcl.2015.08.054

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  19 in total

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Authors:  Sachin A Ingale; Suresh S Pujari; Venkata Ramana Sirivolu; Ping Ding; Hai Xiong; Hui Mei; Frank Seela
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Authors:  Shermaine Mitchell-Ryan; Yiqiang Wang; Larry H Matherly; Aleem Gangjee; Sudhir Raghavan; Manasa Punaha Ravindra; Eric Hales; Steven Orr; Christina Cherian; Zhanjun Hou
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6.  Fluorescent properties and conformational preferences of C-linked phenolic-DNA adducts.

Authors:  Alireza Omumi; Andrea L Millen; Stacey D Wetmore; Richard A Manderville
Journal:  Chem Res Toxicol       Date:  2011-09-25       Impact factor: 3.739

7.  An integrated system for DNA sequencing by synthesis using novel nucleotide analogues.

Authors:  Jia Guo; Lin Yu; Nicholas J Turro; Jingyue Ju
Journal:  Acc Chem Res       Date:  2010-04-20       Impact factor: 22.384

8.  A short and efficient synthesis of the tRNA nucleosides PreQ0 and archaeosine.

Authors:  Tobias Brückl; Florian Klepper; Katrin Gutsmiedl; Thomas Carell
Journal:  Org Biomol Chem       Date:  2007-10-12       Impact factor: 3.876

9.  Furan Decorated Nucleoside Analogues as Fluorescent Probes: synthesis, photophysical evaluation and site-specific incorporation.

Authors:  Nicholas J Greco; Yitzhak Tor
Journal:  Tetrahedron       Date:  2007-04-23       Impact factor: 2.457

10.  Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1.

Authors:  Abedawn I Khalaf; Judith K Huggan; Colin J Suckling; Colin L Gibson; Kirsten Stewart; Federica Giordani; Michael P Barrett; Pui Ee Wong; Keri L Barrack; William N Hunter
Journal:  J Med Chem       Date:  2014-07-29       Impact factor: 7.446
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