Michal Mekel1,2, Hayim Gilshtein3, Abbas Al-Kurd4, Bishara Bishara5,6, Michael M Krausz7, Herbert R Freund4, Yoram Kluger5,6, Ahmed Eid4, Haggi Mazeh4. 1. Department of General Surgery, Rambam Health Care Campus, Haifa, Israel. m_mekel@rambam.health.gov.il. 2. Technion - Israel Institute of Technology, Haifa, Israel. m_mekel@rambam.health.gov.il. 3. Department of General Surgery, Rambam Health Care Campus, Haifa, Israel. hgilshtein@gmail.com. 4. Department of General Surgery, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel. 5. Department of General Surgery, Rambam Health Care Campus, Haifa, Israel. 6. Technion - Israel Institute of Technology, Haifa, Israel. 7. Department of General Surgery, Hillel Yaffe Medical Center, Hadera, Israel.
Abstract
BACKGROUND: Epidemiologic studies demonstrated higher incidence of thyroid cancer in patients with multinodular goiters compared to the general population. The aim of this study was to evaluate the risk of finding significant thyroid cancer in patients undergoing thyroidectomy for presumed benign disease. METHODS: The records of 273 patients operated for indications other than cancer or indeterminate cytology were reviewed and analyzed. RESULTS: 202 (74%) patients had a preoperative fine-needle aspiration (FNA) performed. FNA was benign in 96% of patients and non-diagnostic in 4%. Malignancy was unexpectedly found in 50 (19%) patients. Papillary carcinoma constituted 94% of cancers and 86% of cancers were incidental microcarcinomas. Only 7 (2.6%) patients of the entire cohort had tumors greater than 1 cm, of those only 3 had a previous benign FNA (false-negative rate 1.5%). CONCLUSIONS: The rate of significant thyroid cancer found unexpectedly in resected goiters is extremely low. A negative FNA excludes significant cancer with near certainty.
BACKGROUND: Epidemiologic studies demonstrated higher incidence of thyroid cancer in patients with multinodular goiters compared to the general population. The aim of this study was to evaluate the risk of finding significant thyroid cancer in patients undergoing thyroidectomy for presumed benign disease. METHODS: The records of 273 patients operated for indications other than cancer or indeterminate cytology were reviewed and analyzed. RESULTS: 202 (74%) patients had a preoperative fine-needle aspiration (FNA) performed. FNA was benign in 96% of patients and non-diagnostic in 4%. Malignancy was unexpectedly found in 50 (19%) patients. Papillary carcinoma constituted 94% of cancers and 86% of cancers were incidental microcarcinomas. Only 7 (2.6%) patients of the entire cohort had tumors greater than 1 cm, of those only 3 had a previous benign FNA (false-negative rate 1.5%). CONCLUSIONS: The rate of significant thyroid cancer found unexpectedly in resected goiters is extremely low. A negative FNA excludes significant cancer with near certainty.
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