Literature DB >> 26318666

Anti-diabetic properties of Momordica charantia L. polysaccharide in alloxan-induced diabetic mice.

Xin Xu1, Bin Shan2, Cai-Hu Liao2, Jian-Hua Xie3, Ping-Wei Wen4, Jia-Yi Shi5.   

Abstract

A water-soluble polysaccharide (MCP) was isolated from the fruits of Momordica charantia L., and the hypoglycemic effects of MCP were investigated in both normal healthy and alloxan-induced diabetic mice. MCP was orally administered once a day after 3 days of alloxan-induction at 100, 200 and 300mg/kg body weight for 28 day. Results showed that fasting blood glucose level (BGL) was significantly decreased, whereas the glucose tolerance was marked improvement in alloxan-induced diabetic mice, and loss in body weight was also prevented in diabetic mice compared to the diabetic control group. The dosage of 300mg/kg body weight exhibited the best effects. In addition, MCP did not exhibit any toxic symptoms in the limited toxicity evaluation in mice. The results suggest that MCP possess significantly dose-dependent anti-diabetic activity on alloxan-induced diabetic mice. Hence, MCP can be incorporated as a supplement in health-care food, drugs and/or combined with other hypoglycemic drugs.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Alloxan-induced; Anti-diabetic; Hypoglycemic effect; Momordica charantia L.; Polysaccharide

Mesh：

Substances：

Year:  2015        PMID： 26318666     DOI： 10.1016/j.ijbiomac.2015.08.049

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


  16 in total

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Journal:  Food Nutr Res       Date:  2017-07-13       Impact factor: 3.894

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Review 5.  The Role of Momordica charantia in Resisting Obesity.

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7.  Antidiabetic potential of Caralluma europaea against alloxan-induced diabetes in mice.

Authors:  Loubna Ait Dra; Souad Sellami; Hanane Rais; Faissal Aziz; Abdallah Aghraz; Khalid Bekkouche; Mohamed Markouk; Mustapha Larhsini
Journal:  Saudi J Biol Sci       Date:  2018-06-01       Impact factor: 4.219

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Journal:  Front Plant Sci       Date:  2016-03-31       Impact factor: 5.753

9.  Antiaging of Cucurbitane Glycosides from Fruits of Momordica charantia L.

Authors:  Xueli Cao; Yujuan Sun; Yanfei Lin; Yanjun Pan; Umer Farooq; Lan Xiang; Jianhua Qi
Journal:  Oxid Med Cell Longev       Date:  2018-03-25       Impact factor: 6.543

Review 10.  An update on natural compounds in the remedy of diabetes mellitus: A systematic review.

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Journal:  J Tradit Complement Med       Date:  2017-11-29
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