| Literature DB >> 26318059 |
Ekaterina N Proshkina1, Mikhail V Shaposhnikov1, Asiya F Sadritdinova2, Anna V Kudryavtseva2, Alexey A Moskalev3.
Abstract
Drosophila is one of the most convenient model organisms in the genetics of aging and longevity. Unlike the nematodes, which allow for the detection of new pro-aging genes by knockout and RNAi-mediated knock-down, Drosophila also provides an opportunity to find new pro-longevity genes by driver-induced overexpression. Similar studies on other models are extremely rare. In this review, we focused on genes whose overexpression prolongs the life of fruit flies. The majority of longevity-associated genes regulates metabolism and stress resistance, and belongs to the IGF-1R, PI3K, PKB, AMPK and TOR metabolic regulation cluster and the FOXO, HDAC, p53 stress response cluster.Entities:
Keywords: Drosophila melanogaster; Overexpression; Pro-longevity genes
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Year: 2015 PMID： 26318059 DOI： 10.1016/j.arr.2015.08.005
Source DB: PubMed Journal: Ageing Res Rev ISSN： 1568-1637 Impact factor: 10.895