Morteza Akbari1, Ahmad Naghibzadeh-Tahami2, Narges Khanjani3, Mohammad Reza Baneshi4, Elham Kamali5, Maryam Hesampour5, Bahman Nazemzadegan6, Ali-Akbar Haghdoost7. 1. Medical Informatics Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. 2. Physiology Research Center, Institute of Nouropharmacology, Kerman University of Medical Sciences, Kerman, Iran. 3. Monash Centre for Occupational and Environmental Health, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. 4. Research Center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. 5. Department of Health Education and Promotion, Faculty of Health, Shiraz University of Medical Sciences, Shiraz, Iran. 6. Deputy of Health, Shiraz University of Medical Sciences, Shiraz, Iran. 7. Research Center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. Ahaghdoost@gmail.com.
Abstract
BACKGROUND: Bladder cancer (BC) is the most common genitourinary system malignancy in humans. Consumption of opium and its derivatives, maybe a risk factor possibly in Iran. The aim of this study was to investigate the relationship between consumption of opium and its derivatives and the incidence of BC. METHODS: In an individually matched case-control study in Shiraz (located in the south of Iran), 198 patients with BC and 396 healthy individuals (matched in age, sex and residence (urban/rural)) were investigated. Data about consumption of opium and its derivatives, tobacco, alcohol and diet were collected using a structured valid and reliable questionnaire. Crude and adjusted odds ratios (ORs) were computed using conditional logistic regression models. RESULTS: Opium consumption was associated with an increased risk of BC with an adjusted OR = 3.9 (95% CI: 1.2 - 12.0). Moreover, a considerable dose-response relationship was observed between the opium consumption and its derivatives and the incidence of BC; comparing to no users, the odds ratios of low and high consumptions were 3.3 (95% CI: 0.5 - 23.1) and 4.9 (95% CI: 1.1 - 21.9) respectively. CONCLUSION: Opium consumption can be a potential strong risk factor for BC in Iran.
BACKGROUND:Bladder cancer (BC) is the most common genitourinary system malignancy in humans. Consumption of opium and its derivatives, maybe a risk factor possibly in Iran. The aim of this study was to investigate the relationship between consumption of opium and its derivatives and the incidence of BC. METHODS: In an individually matched case-control study in Shiraz (located in the south of Iran), 198 patients with BC and 396 healthy individuals (matched in age, sex and residence (urban/rural)) were investigated. Data about consumption of opium and its derivatives, tobacco, alcohol and diet were collected using a structured valid and reliable questionnaire. Crude and adjusted odds ratios (ORs) were computed using conditional logistic regression models. RESULTS: Opium consumption was associated with an increased risk of BC with an adjusted OR = 3.9 (95% CI: 1.2 - 12.0). Moreover, a considerable dose-response relationship was observed between the opium consumption and its derivatives and the incidence of BC; comparing to no users, the odds ratios of low and high consumptions were 3.3 (95% CI: 0.5 - 23.1) and 4.9 (95% CI: 1.1 - 21.9) respectively. CONCLUSION: Opium consumption can be a potential strong risk factor for BC in Iran.
Authors: Ahmad Naghibzadeh-Tahami; Vahid Yazdi Feyzabadi; Narges Khanjani; Ahad Ashrafi-Asgarabad; Hosniyeh Alizaeh; Vahid Reza Borhaninejad; Mohammad Moradi-Joo; Masoud Zeinali; Mohammad Javad Zahedi; Mahmoud Aghaee-Afshar; Ali Akbar Haghdoost Journal: Iran J Public Health Date: 2016-10 Impact factor: 1.429
Authors: Sajjad Mohammad Ganji; Massoud Saidijam; Razieh Amini; Seyed Habibollah Mousavi-Bahar; Nooshin Shabab; Saman Seyedabadi; Ali Mahdavinezhad Journal: Int J Mol Cell Med Date: 2017-07-08