Literature DB >> 26316455

Fumarate in DNA repair.

Susan P Lees-Miller1.   

Abstract

A new study suggests that fumarase, a metabolic enzyme normally associated with ATP production in mitochondria, is recruited to sites of DNA damage where it produces fumarate to inhibit histone demethylation and promote repair of DNA double strand breaks.

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Year:  2015        PMID： 26316455     DOI： 10.1038/ncb3232

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  11 in total

1.  Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining.

Authors:  Sheema Fnu; Elizabeth A Williamson; Leyma P De Haro; Mark Brenneman; Justin Wray; Montaser Shaheen; Krishnan Radhakrishnan; Suk-Hee Lee; Jac A Nickoloff; Robert Hromas
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-27       Impact factor: 11.205

Review 2.  Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining.

Authors:  Chen Wang; Susan P Lees-Miller
Journal:  Int J Radiat Oncol Biol Phys       Date:  2013-02-20       Impact factor: 7.038

3.  Small molecules, big effects: a role for chromatin-localized metabolite biosynthesis in gene regulation.

Authors:  Bryan A Gibson; W Lee Kraus
Journal:  Mol Cell       Date:  2011-03-04       Impact factor: 17.970

Review 4.  Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids.

Authors:  W S Dynan; S Yoo
Journal:  Nucleic Acids Res       Date:  1998-04-01       Impact factor: 16.971

5.  Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response.

Authors:  Ohad Yogev; Orli Yogev; Esti Singer; Eitan Shaulian; Michal Goldberg; Thomas D Fox; Ophry Pines
Journal:  PLoS Biol       Date:  2010-03-09       Impact factor: 8.029

6.  Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH.

Authors:  J Gregory Cairncross; Meihua Wang; Robert B Jenkins; Edward G Shaw; Caterina Giannini; David G Brachman; Jan C Buckner; Karen L Fink; Luis Souhami; Normand J Laperriere; Jason T Huse; Minesh P Mehta; Walter J Curran
Journal:  J Clin Oncol       Date:  2014-02-10       Impact factor: 44.544

7.  Histone H2A.Z controls a critical chromatin remodeling step required for DNA double-strand break repair.

Authors:  Ye Xu; Marina K Ayrapetov; Chang Xu; Ozge Gursoy-Yuzugullu; Yiduo Hu; Brendan D Price
Journal:  Mol Cell       Date:  2012-10-30       Impact factor: 17.970

8.  Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.

Authors:  Mengtao Xiao; Hui Yang; Wei Xu; Shenghong Ma; Huaipeng Lin; Honguang Zhu; Lixia Liu; Ying Liu; Chen Yang; Yanhui Xu; Shimin Zhao; Dan Ye; Yue Xiong; Kun-Liang Guan
Journal:  Genes Dev       Date:  2012-06-07       Impact factor: 12.890

Review 9.  IDH mutations in tumorigenesis and their potential role as novel therapeutic targets.

Authors:  Daniel Krell; Paul Mulholland; Adam E Frampton; Jonathan Krell; Justin Stebbing; Chiara Bardella
Journal:  Future Oncol       Date:  2013-12       Impact factor: 3.674

10.  Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.

Authors:  Yuhui Jiang; Xu Qian; Jianfeng Shen; Yugang Wang; Xinjian Li; Rui Liu; Yan Xia; Qianming Chen; Guang Peng; Shiaw-Yih Lin; Zhimin Lu
Journal:  Nat Cell Biol       Date:  2015-08-03       Impact factor: 28.213
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  1 in total

1.  Genome-wide shifts in histone modifications at early stage of rice infection with Meloidogyne graminicola.

Authors:  Mohammad Reza Atighi; Bruno Verstraeten; Tim De Meyer; Tina Kyndt
Journal:  Mol Plant Pathol       Date:  2021-02-12       Impact factor: 5.663
  1 in total

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