| Literature DB >> 26316185 |
Roghayeh Abbasalipourkabir1, Hemen Moradi2, Sadegh Zarei3, Soheila Asadi4, Aref Salehzadeh5, Abolfazl Ghafourikhosroshahi6, Motahareh Mortazavi7, Nasrin Ziamajidi4.
Abstract
The purpose of this study was to investigate the effects of zinc oxide nanoparticles (nZnO) on adult male Wistar rats. Thirty male Wistar rats divided into five groups of six animals each were used for this study. For ten days, Groups one to four continuously received 50, 100, 150 and 200 mg/kg nZnO, respectively. Group five served as the control group. At the end of the study, the rats were sacrificed and histopathological study of the liver and renal tissue, sperm analysis, serum oxidative stress parameters and some liver enzymes were done. The results of this study showed that nZnO at concentration more than 50 mg/kg lead to significant changes in liver enzymes, oxidative stress, liver and renal tissue and sperm quality and quantity. In conclusion, the toxicity of nZnO is more significant when the concentration is increased; however, the use of low doses requires further investigation.Entities:
Keywords: Histopathology; Liver enzyme; Oxidative stress system; Sperm analysis; ZnO nanoparticles
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Year: 2015 PMID： 26316185 DOI： 10.1016/j.fct.2015.08.019
Source DB: PubMed Journal: Food Chem Toxicol ISSN： 0278-6915 Impact factor: 6.023