| Literature DB >> 26315731 |
Antonios P Antoniadis1, Peter Mortier2, Ghassan Kassab3, Gabriele Dubini4, Nicolas Foin5, Yoshinobu Murasato6, Andreas A Giannopoulos7, Shengxian Tu8, Kiyotaka Iwasaki9, Yutaka Hikichi10, Francesco Migliavacca4, Claudio Chiastra11, Jolanda J Wentzel12, Frank Gijsen12, Johan H C Reiber13, Peter Barlis14, Patrick W Serruys15, Deepak L Bhatt16, Goran Stankovic17, Elazer R Edelman18, George D Giannoglou19, Yves Louvard20, Yiannis S Chatzizisis21.
Abstract
Treatment of coronary bifurcation lesions remains an ongoing challenge for interventional cardiologists. Stenting of coronary bifurcations carries higher risk for in-stent restenosis, stent thrombosis, and recurrent clinical events. This review summarizes the current evidence regarding application and use of biomechanical modeling in the study of stent properties, local flow dynamics, and outcomes after percutaneous coronary interventions in bifurcation lesions. Biomechanical modeling of bifurcation stenting involves computational simulations and in vitro bench testing using subject-specific arterial geometries obtained from in vivo imaging. Biomechanical modeling has the potential to optimize stenting strategies and stent design, thereby reducing adverse outcomes. Large-scale clinical studies are needed to establish the translation of pre-clinical findings to the clinical arena.Entities:
Keywords: bifurcation; biomechanical stress; coronary artery disease; endothelial shear stress; stent(s)
Mesh：
Year: 2015 PMID： 26315731 DOI： 10.1016/j.jcin.2015.06.015
Source DB: PubMed Journal: JACC Cardiovasc Interv ISSN： 1936-8798 Impact factor: 11.195