| Literature DB >> 26315676 |
Laine Celestino Pinto1, Bruno Moreira Soares1, João de Jesus Viana Pinheiro2, Gregory J Riggins3, Paulo Pimentel Assumpção1, Rommel Mário Rodriguez Burbano1, Raquel Carvalho Montenegro4.
Abstract
The present study aimed to investigate the effects of MBZ on a human malignant ascites cell line derived from a primary gastric cancer tumor. Our data reveal that MBZ showed high cytotoxicity in vitro, displaying an IC50 of 0.39 μM and 1.25 μM in ACP-02 and ACP-03, respectively. The association between MBZ and 5-FU increased slightly the cytotoxicity when compared to MBZ and 5-FU alone. Furthermore, MBZ disrupted the microtubule structure of AGP-01 cells and inhibited significantly the invasion and migration of these cells. Activity of active MMP-2 significantly decreased at all tested concentration of MBZ compared to negative control. These results support the indication of MBZ in combination with chemotherapeutic agents as a possible adjuvant therapy for the management/treatment of patients with advanced gastric cancer since MBZ is a drug of low cost with acceptable safety profile and reduced toxicity to normal cells. However, clinical trials must be performed in o to evaluate its efficacy in gastric cancer patients.Entities:
Keywords: Invasion; Mebendazole; Metalloproteinase; Migration
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Year: 2015 PMID： 26315676 DOI： 10.1016/j.tiv.2015.08.007
Source DB: PubMed Journal: Toxicol In Vitro ISSN： 0887-2333 Impact factor: 3.500