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Literature DB >> 26315484

RNA Pol II as a sensor of 5caC.

Abstract

Cytosines in genomic DNA come in different flavors. A recent paper published in Nature reveals that an oxidized variety, 5-carboxylcytosine, is recognized by the elongating RNA polymerase, shedding light on the role of DNA oxidation in transcription regulation.

Entities: Chemical

Mesh：

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Year: 2015 PMID： 26315484 PMCID： PMC4650622 DOI： 10.1038/cr.2015.103

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

9 in total

Review 1. Genomic DNA methylation: the mark and its mediators.

Authors: Robert J Klose; Adrian P Bird
Journal: Trends Biochem Sci Date: 2006-01-05 Impact factor: 13.807

2. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.

Authors: Yu-Fei He; Bin-Zhong Li; Zheng Li; Peng Liu; Yang Wang; Qingyu Tang; Jianping Ding; Yingying Jia; Zhangcheng Chen; Lin Li; Yan Sun; Xiuxue Li; Qing Dai; Chun-Xiao Song; Kangling Zhang; Chuan He; Guo-Liang Xu
Journal: Science Date: 2011-08-04 Impact factor: 47.728

3. Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites.

Authors: Atanu Maiti; Alexander C Drohat
Journal: J Biol Chem Date: 2011-08-23 Impact factor: 5.157

1 in total

Review 1. Mechanism of transcription-coupled DNA modification recognition.

Authors: Ji Hyun Shin; Liang Xu; Dong Wang
Journal: Cell Biosci Date: 2017-02-22 Impact factor: 7.133

1 in total

RNA Pol II as a sensor of 5caC.

Review 1. Genomic DNA methylation: the mark and its mediators.

2. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.

3. Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites.

Review 4. TET enzymes, TDG and the dynamics of DNA demethylation.

5. Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription.

6. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.

7. 5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription.

8. Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex.

9. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.

Review 1. Mechanism of transcription-coupled DNA modification recognition.