Ruben G L Real1, Sandra Veser2, Helena Erlbeck3, Monica Risetti4, Dominik Vogel5, Friedemann Müller5, Boris Kotchoubey2, Donatella Mattia4, Andrea Kübler3. 1. Institute of Psychology, University of Würzburg, Germany. Electronic address: ruben.real@uni-wuerzburg.de. 2. Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, Germany. 3. Institute of Psychology, University of Würzburg, Germany. 4. IRCCS, Fondazione Santa Lucia, Rome, Italy. 5. Schön Clinics for Neurological Rehabilitation, Bad Aibling, Germany.
Abstract
OBJECTIVE: Evaluation of a short two-tone oddball paradigm to discriminate between the vegetative state (VS) and minimal consciousness state (MCS) in a sample of patients with severe disorders of consciousness (DOC). METHOD: EEG was recorded from 45 DOC patients and 14 healthy participants while listening to an auditory oddball paradigm presented in a passive - just listen - and an active - count the odd tones - condition. In patients, the experiment was repeated after a minimum of one week. RESULTS: Prevalence of the P300 was higher in healthy participants (71%) than in patients, but did not discriminate between VS (T1: ∼10%; T2: ∼11%) and MCS (T1: ∼13%; T2: 25%) patients. CONCLUSION: Results cast doubt on whether this simple auditory stimulation paradigm, which requires cognitive action from the listener, is sensitive enough to discriminate between patients with DOC. SIGNIFICANCE: The sensitivity of the P300 ERP obtained in a short two-tone oddball paradigm presented in a passive and an active condition appears to be too low for routine application in a clinical setting aiming at distinguishing between VS and MCS patients.
OBJECTIVE: Evaluation of a short two-tone oddball paradigm to discriminate between the vegetative state (VS) and minimal consciousness state (MCS) in a sample of patients with severe disorders of consciousness (DOC). METHOD: EEG was recorded from 45 DOC patients and 14 healthy participants while listening to an auditory oddball paradigm presented in a passive - just listen - and an active - count the odd tones - condition. In patients, the experiment was repeated after a minimum of one week. RESULTS: Prevalence of the P300 was higher in healthy participants (71%) than in patients, but did not discriminate between VS (T1: ∼10%; T2: ∼11%) and MCS (T1: ∼13%; T2: 25%) patients. CONCLUSION: Results cast doubt on whether this simple auditory stimulation paradigm, which requires cognitive action from the listener, is sensitive enough to discriminate between patients with DOC. SIGNIFICANCE: The sensitivity of the P300 ERP obtained in a short two-tone oddball paradigm presented in a passive and an active condition appears to be too low for routine application in a clinical setting aiming at distinguishing between VS and MCSpatients.
Authors: Zulay R Lugo; Lucia R Quitadamo; Luigi Bianchi; Fréderic Pellas; Sandra Veser; Damien Lesenfants; Ruben G L Real; Cornelia Herbert; Christoph Guger; Boris Kotchoubey; Donatella Mattia; Andrea Kübler; Steven Laureys; Quentin Noirhomme Journal: Front Hum Neurosci Date: 2016-11-14 Impact factor: 3.169
Authors: Betty Wutzl; Stefan M Golaszewski; Kenji Leibnitz; Patrick B Langthaler; Alexander B Kunz; Stefan Leis; Kerstin Schwenker; Aljoscha Thomschewski; Jürgen Bergmann; Eugen Trinka Journal: Brain Sci Date: 2021-05-25