| Literature DB >> 26314923 |
Robert J Pasteris1, Mary Ann Hanagan2, John J Bisaha2, Bruce L Finkelstein2, Lisa E Hoffman2, Vann Gregory2, John L Andreassi2, James A Sweigard2, Boris A Klyashchitsky2, Yewande T Henry2, Richard A Berger2.
Abstract
Oxathiapiprolin is the first member of a new class of piperidinyl thiazole isoxazoline fungicides with exceptional activity against plant diseases caused by oomycete pathogens. It acts via inhibition of a novel fungal target-an oxysterol binding protein-resulting in excellent preventative, curative and residual efficacy against key diseases of grapes, potatoes and vegetables. Oxathiapiprolin is being developed globally as DuPont™ Zorvec™ disease control with first registration and sales anticipated in 2015. The discovery, synthesis, optimization and biological efficacy are presented.Entities:
Keywords: Crop protection; Disease control; Oomycete fungicide; Oxathiapiprolin; Oxysterol binding protein
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Year: 2015 PMID： 26314923 DOI： 10.1016/j.bmc.2015.07.064
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641