Literature DB >> 26313223

Linking germline and somatic variation in Ewing sarcoma.

Nicholas C Gomez1, Ian J Davis1.   

Abstract

The identification of gene-regulatory polymorphisms that influence cancer susceptibility can identify key oncogenic pathways. A new study links a germline variant to Ewing sarcoma disease susceptibility and EWSR1-FLI1-mediated gene activation.

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Year:  2015        PMID： 26313223     DOI： 10.1038/ng.3387

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  8 in total

1.  EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma.

Authors:  Nicolò Riggi; Birgit Knoechel; Shawn M Gillespie; Bradley E Bernstein; Miguel N Rivera; Esther Rheinbay; Gaylor Boulay; Mario L Suvà; Nikki E Rossetti; Wannaporn E Boonseng; Ozgur Oksuz; Edward B Cook; Aurélie Formey; Anoop Patel; Melissa Gymrek; Vishal Thapar; Vikram Deshpande; David T Ting; Francis J Hornicek; G Petur Nielsen; Ivan Stamenkovic; Martin J Aryee
Journal:  Cancer Cell       Date:  2014-10-30       Impact factor: 31.743

2.  Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription.

Authors:  Mukund Patel; Jeremy M Simon; Michael D Iglesia; Sam B Wu; Andrew W McFadden; Jason D Lieb; Ian J Davis
Journal:  Genome Res       Date:  2011-11-15       Impact factor: 9.043

3.  EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations.

Authors:  Robert Beck; Michael J Monument; W Scott Watkins; Richard Smith; Kenneth M Boucher; Joshua D Schiffman; Lynn B Jorde; R Lor Randall; Stephen L Lessnick
Journal:  Cancer Genet       Date:  2012-06

4.  Microsatellites as EWS/FLI response elements in Ewing's sarcoma.

Authors:  Kunal Gangwal; Savita Sankar; Peter C Hollenhorst; Michelle Kinsey; Stephen C Haroldsen; Atul A Shah; Kenneth M Boucher; W Scott Watkins; Lynn B Jorde; Barbara J Graves; Stephen L Lessnick
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-14       Impact factor: 11.205

5.  Etiology of childhood bone cancer: epidemiologic observations.

Authors:  R W Miller
Journal:  Recent Results Cancer Res       Date:  1976

6.  Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.

Authors:  Thomas G P Grünewald; Virginie Bernard; Pascale Gilardi-Hebenstreit; Virginie Raynal; Didier Surdez; Marie-Ming Aynaud; Olivier Mirabeau; Florencia Cidre-Aranaz; Franck Tirode; Sakina Zaidi; Gaëlle Perot; Anneliene H Jonker; Carlo Lucchesi; Marie-Cécile Le Deley; Odile Oberlin; Perrine Marec-Bérard; Amélie S Véron; Stephanie Reynaud; Eve Lapouble; Valentina Boeva; Thomas Rio Frio; Javier Alonso; Smita Bhatia; Gaëlle Pierron; Geraldine Cancel-Tassin; Olivier Cussenot; David G Cox; Lindsay M Morton; Mitchell J Machiela; Stephen J Chanock; Patrick Charnay; Olivier Delattre
Journal:  Nat Genet       Date:  2015-07-27       Impact factor: 38.330

7.  Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma.

Authors:  Sophie Postel-Vinay; Amélie S Véron; Franck Tirode; Gaelle Pierron; Stéphanie Reynaud; Heinrich Kovar; Odile Oberlin; Eve Lapouble; Stelly Ballet; Carlo Lucchesi; Udo Kontny; Anna González-Neira; Piero Picci; Javier Alonso; Ana Patino-Garcia; Brigitte Bressac de Paillerets; Karine Laud; Christian Dina; Philippe Froguel; Françoise Clavel-Chapelon; Francois Doz; Jean Michon; Stephen J Chanock; Gilles Thomas; David G Cox; Olivier Delattre
Journal:  Nat Genet       Date:  2012-02-12       Impact factor: 38.330

8.  Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group.

Authors:  Michael J Monument; Kirsten M Johnson; Elizabeth McIlvaine; Lisa Abegglen; W Scott Watkins; Lynn B Jorde; Richard B Womer; Natalie Beeler; Laura Monovich; Elizabeth R Lawlor; Julia A Bridge; Joshua D Schiffman; Mark D Krailo; R Lor Randall; Stephen L Lessnick
Journal:  PLoS One       Date:  2014-08-05       Impact factor: 3.240
  8 in total
  2 in total

1.  DNA Methylation and Regulatory Elements during Chicken Germline Stem Cell Differentiation.

Authors:  Yanghua He; Qisheng Zuo; John Edwards; Keji Zhao; Jinzhi Lei; Wentao Cai; Qing Nie; Bichun Li; Jiuzhou Song
Journal:  Stem Cell Reports       Date:  2018-04-19       Impact factor: 7.765

2.  Germline genetic variants were interactively associated with somatic alterations in gastric cancer.

Authors:  Xu Zhang; Yuzhuo Wang; Tian Tian; Gangqiao Zhou; Guangfu Jin
Journal:  Cancer Med       Date:  2018-06-20       Impact factor: 4.452
  2 in total

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