Literature DB >> 26312993

Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [(45)Ti](salan)Ti(dipic).

Gregory W Severin1, Carsten H Nielsen2,3, Andreas I Jensen1, Jesper Fonslet1, Andreas Kjær2, Fedor Zhuravlev1.   

Abstract

We present a novel solid-phase based (45)Ti radiolabeling methodology and the implementation of (45)Ti-PET in titanium-based antineoplastics using the showcase compound [(45)Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.

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Year:  2015        PMID： 26312993     DOI： 10.1021/acs.jmedchem.5b01167

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

Review 1.  A ubiquitous metal, difficult to track: towards an understanding of the regulation of titanium(iv) in humans.

Authors:  Sergio A Loza-Rosas; Manoj Saxena; Yamixa Delgado; Kavita Gaur; Mallesh Pandrala; Arthur D Tinoco
Journal:  Metallomics       Date:  2017-04-19       Impact factor: 4.526

2.  Intrinsic radiolabeling of Titanium-45 using mesoporous silica nanoparticles.

Authors:  Feng Chen; Hector F Valdovinos; Reinier Hernandez; Shreya Goel; Todd E Barnhart; Weibo Cai
Journal:  Acta Pharmacol Sin       Date:  2017-04-17       Impact factor: 6.150

3.  Expanding the Therapeutic Potential of the Iron Chelator Deferasirox in the Development of Aqueous Stable Ti(IV) Anticancer Complexes.

Authors:  Sergio A Loza-Rosas; Alexandra M Vázquez-Salgado; Kennett I Rivero; Lenny J Negrón; Yamixa Delgado; Josué A Benjamín-Rivera; Angel L Vázquez-Maldonado; Timothy B Parks; Charlene Munet-Colón; Arthur D Tinoco
Journal:  Inorg Chem       Date:  2017-06-23       Impact factor: 5.165

4.  Design, Synthesis, Computational, and Preclinical Evaluation of natTi/45Ti-Labeled Urea-Based Glutamate PSMA Ligand.

Authors:  Kristina Søborg Pedersen; Christina Baun; Karin Michaelsen Nielsen; Helge Thisgaard; Andreas Ingemann Jensen; Fedor Zhuravlev
Journal:  Molecules       Date:  2020-03-02       Impact factor: 4.411
  4 in total

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