Literature DB >> 26311425

Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases.

Xifei Yang1, Yanling Zhang, Hua Xu, Xiaobin Luo, Jun Yu, Jianjun Liu, Raymond Chuen-Chung Chang.   

Abstract

Coenzyme Q10 (CoQ10) is a component of electron transport chain and acts as an antioxidant. It is also used for preventing neurodegeneration against mitochondrial deficiency and oxidative stress. Therefore, CoQ10 has received increasing attention as therapeutic and preventive intervention for neurodegenerative diseases. This review article focuses mainly on the structure of CoQ10, the function of CoQ10 and the relationship between mitochondrial impairment, oxidative stress and neurodegenerative diseases. In addition, the effects of CoQ10 on Alzheimer's disease, Parkinson's disease, and Huntington's disease are also discussed. Finally, future perspectives regarding development of successful treatment for neurodegenerative diseases are proposed.

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Year:  2016        PMID： 26311425     DOI： 10.2174/1568026615666150827095252

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  25 in total

1.  Nutrition and Lifestyle Intervention on Mood and Neurological Disorders.

Authors:  Gary Null; Luanne Pennesi; Martin Feldman
Journal:  J Evid Based Complementary Altern Med       Date:  2016-03-14

2.  Potential Protective Effect of Coenzyme Q10 on Doxorubicin-Induced Neurotoxicity and Behavioral Disturbances in Rats.

Authors:  Nilsel Okudan; Muaz Belviranlı; Tuğba Sezer
Journal:  Neurochem Res       Date:  2022-01-03       Impact factor: 3.996

Review 3.  Targeting Mitochondria as a Therapeutic Approach for Parkinson's Disease.

Authors:  Maryam Abrishamdar; Maryam Sadat Jalali; Yaghoob Farbood
Journal:  Cell Mol Neurobiol       Date:  2022-08-11       Impact factor: 4.231

4.  Coenzyme Q10, Biochanin A and Phloretin Attenuate Cr(VI)-Induced Oxidative Stress and DNA Damage by Stimulating Nrf2/HO-1 Pathway in the Experimental Model.

Authors:  Swapnil Tripathi; Dharati Parmar; Shabrin Fathima; Samir Raval; Gyanendra Singh
Journal:  Biol Trace Elem Res       Date:  2022-08-12       Impact factor: 4.081

5.  Alpha Lipoamide Ameliorates Motor Deficits and Mitochondrial Dynamics in the Parkinson's Disease Model Induced by 6-Hydroxydopamine.

Authors:  Bo Zhou; Min Wen; Xin Lin; Yun-Hua Chen; Yun Gou; Yong Li; Yi Zhang; Hong-Wei Li; Lei Tang
Journal:  Neurotox Res       Date:  2017-10-10       Impact factor: 3.911

6.  Idebenone Ameliorates Rotenone-Induced Parkinson's Disease in Rats Through Decreasing Lipid Peroxidation.

Authors:  Bahattin Avcı; Caner Günaydın; Tolga Güvenç; Canan Kulcu Yavuz; Nilufer Kuruca; S Sirri Bilge
Journal:  Neurochem Res       Date:  2020-11-28       Impact factor: 3.996

7.  Cardioprotective Effect of Coenzyme Q10 on Apoptotic Myocardial Cell Death by Regulation of Bcl-2 Gene Expression.

Authors:  Najam Ali Khan; M Abid; Aftab Ahmad; Mohammed F Abuzinadah; Mohammed Basheikh; Kamal Kishore
Journal:  J Pharmacol Pharmacother       Date:  2017 Jul-Sep

8.  CoQ10 Augments Rosuvastatin Neuroprotective Effect in a Model of Global Ischemia via Inhibition of NF-κB/JNK3/Bax and Activation of Akt/FOXO3A/Bim Cues.

Authors:  Sarah A Abd El-Aal; Mai A Abd El-Fattah; Hanan S El-Abhar
Journal:  Front Pharmacol       Date:  2017-10-13       Impact factor: 5.810

Review 9.  Nanoparticle-Mediated Delivery of Neuroprotective Substances for the Treatment of Diabetic Retinopathy.

Authors:  Rosario Amato; Massimo Dal Monte; Matteo Lulli; Vittoria Raffa; Giovanni Casini
Journal:  Curr Neuropharmacol       Date:  2018       Impact factor: 7.363

Review 10.  The metabolic face of migraine - from pathophysiology to treatment.

Authors:  Elena C Gross; Marco Lisicki; Dirk Fischer; Peter S Sándor; Jean Schoenen
Journal:  Nat Rev Neurol       Date:  2019-10-04       Impact factor: 42.937
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