Sebastiano Mercadante1, Federica Aielli2, Claudio Adile3, Patrizia Ferrera3, Alessandro Valle4, Claudio Cartoni5, Massimo Pizzuto6, Amanda Caruselli7, Renato Parsi8, Andrea Cortegiani9, Francesco Masedu10, Marco Valenti10, Corrado Ficorella2, Giampiero Porzio2. 1. Pain Relief and Supportive Care Unit, La Maddalena Cancer Center, Palermo, Italy. Electronic address: terapiadeldolore@lamaddalenanet.it. 2. Supportive Care Task Force, University of L'Aquila, L'Aquila, Italy. 3. Pain Relief and Supportive Care Unit, La Maddalena Cancer Center, Palermo, Italy. 4. Hospice and Home Care Program, FARO Foundation, Turin, Italy. 5. Division of Hematology, Department of Cellular Biotechnologies and Hematology, Policlinico Umberto I, Home Care Service of the Rome Section of the Italian Association Against Leukemias, Rome, Italy. 6. Palliative Care Unit, Istituti Clinici di Perfezionamento Hospital, Milan, Italy. 7. Home Care Program, SAMO, Palermo, Italy; Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico "P. Giaccone", University of Palermo, Palermo, Italy. 8. Home Care Program, SAMO, Palermo, Italy. 9. Department of Biopathology, Medical and Forensic Biotechnologies, Policlinico "P. Giaccone", University of Palermo, Palermo, Italy. 10. Section of Clinical Epidemiology and Environmental Medicine, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Abstract
CONTEXT: Information regarding sleep disturbances in the population with advanced cancer is meager. OBJECTIVES: To assess the prevalence of sleep disturbances and possible correlations with associated factors in a large number of patients with advanced cancer admitted to different palliative care settings. METHODS: This was an observational study performed in different settings of palliative care. A consecutive sample of patients with advanced cancer was prospectively assessed for a period of six months. Epidemiological and clinical data, treatments received in the last month, Karnofsky status, Edmonton Symptom Assessment System scores, and concomitant medical treatment were recorded. Patients were administered the Athens Insomnia Scale and the Hospital Anxiety and Depression Scale (HADS). RESULTS: A total of 820 patients were surveyed. Mean age was 69.7 years (SD 12.7), and 429 patients were males. Consistent sleep disturbances (moderate to maximum) were found in 60.8% of patients. Aged patients were less likely to have sleep disturbances, whereas a poor Karnofsky level was significantly associated with sleep problems. Breast, gastrointestinal, head and neck, lung, and prostate cancers were associated with sleep problems. Patients who had a secondary school or undergraduate education had less sleep disturbances. Hormone therapy and use of opioids and corticosteroids were positively associated with sleep disturbances, and there was a positive correlation of HADS-Anxiety and HADS-Depression scores with sleep disturbances. CONCLUSION: More than 60% of palliative care patients have relevant sleep disturbances. Several factors associated with sleep disorders have been identified and should prompt physicians to make a careful examination and subsequent treatment of these disturbances.
CONTEXT: Information regarding sleep disturbances in the population with advanced cancer is meager. OBJECTIVES: To assess the prevalence of sleep disturbances and possible correlations with associated factors in a large number of patients with advanced cancer admitted to different palliative care settings. METHODS: This was an observational study performed in different settings of palliative care. A consecutive sample of patients with advanced cancer was prospectively assessed for a period of six months. Epidemiological and clinical data, treatments received in the last month, Karnofsky status, Edmonton Symptom Assessment System scores, and concomitant medical treatment were recorded. Patients were administered the Athens Insomnia Scale and the Hospital Anxiety and Depression Scale (HADS). RESULTS: A total of 820 patients were surveyed. Mean age was 69.7 years (SD 12.7), and 429 patients were males. Consistent sleep disturbances (moderate to maximum) were found in 60.8% of patients. Aged patients were less likely to have sleep disturbances, whereas a poor Karnofsky level was significantly associated with sleep problems. Breast, gastrointestinal, head and neck, lung, and prostate cancers were associated with sleep problems. Patients who had a secondary school or undergraduate education had less sleep disturbances. Hormone therapy and use of opioids and corticosteroids were positively associated with sleep disturbances, and there was a positive correlation of HADS-Anxiety and HADS-Depression scores with sleep disturbances. CONCLUSION: More than 60% of palliative care patients have relevant sleep disturbances. Several factors associated with sleep disorders have been identified and should prompt physicians to make a careful examination and subsequent treatment of these disturbances.
Authors: Sebastiano Mercadante; Claudio Adile; Patrizia Ferrera; Francesco Masedu; Marco Valenti; Federica Aielli Journal: Support Care Cancer Date: 2016-12-13 Impact factor: 3.603
Authors: Xian-Liang Liu; Hui Lin Cheng; Simon Moss; Carol Chunfeng Wang; Catherine Turner; Jing-Yu Tan Journal: Evid Based Complement Alternat Med Date: 2020-04-28 Impact factor: 2.629