Literature DB >> 26310894

Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents.

Mohammad Shaquiquzzaman1, Garima Verma1, Akranth Marella1, Mymoona Akhter1, Wasim Akhtar1, Mohemmed Faraz Khan1, Sharba Tasneem1, Mohammad Mumtaz Alam2.   

Abstract

Piperazine is one of the most sought heterocyclics for the development of new drug candidates. This ring can be traced in a number of well established, commercially available drugs. Wide array of pharmacological activities exhibited by piperazine derivatives have made them indispensable anchors for the development of novel therapeutic agents. The review herein highlights the therapeutic significance of piperazine derivatives. Various therapeutically active piperazine derivatives developed by several chemists are reported here.
Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Heterocyclic; Pharmacological activity; Piperazine

Mesh：

Substances：

Year:  2015        PMID： 26310894     DOI： 10.1016/j.ejmech.2015.07.026

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  23 in total

1.  Copper Mediated Coupling of 2-(Piperazine)-pyrimidine Iodides with Aryl Thiols using Cu(I)Thiophene-2-carboxylate.

Authors:  Liza Shrestha; Hardik J Patel; Yanlong Kang; Sahil Sharma; Gabriela Chiosis; Tony Taldone
Journal:  Tetrahedron Lett       Date:  2017-10-23       Impact factor: 2.415

2.  Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives.

Authors:  Gao-Xiang Zhu; Pi-Le Cheng; Masuo Goto; Na Zhang; Susan L Morris-Natschke; Kan-Yen Hsieh; Guan-Zhou Yang; Qian-Ru Yang; Ying-Qian Liu; Hai-Le Chen; Xiao-Shuai Zhang; Kuo-Hsiung Lee
Journal:  Bioorg Med Chem Lett       Date:  2017-02-28       Impact factor: 2.823

3.  Structure-Function Analysis of Phenylpiperazine Derivatives as Intestinal Permeation Enhancers.

Authors:  Katherine C Fein; Nicholas G Lamson; Kathryn A Whitehead
Journal:  Pharm Res       Date:  2017-04-03       Impact factor: 4.200

4.  Design, synthesis, in silico and biological evaluation of novel 2-(4-(4-substituted piperazin-1-yl)benzylidene)hydrazine carboxamides.

Authors:  Shikha Kumari; Chandra Bhushan Mishra; Danish Idrees; Amresh Prakash; Rajesh Yadav; Md Imtaiyaz Hassan; Manisha Tiwari
Journal:  Mol Divers       Date:  2016-12-30       Impact factor: 2.943

5.  Synthesis and Antinociceptive Effect of Some Thiazole-Piperazine Derivatives: Involvement of Opioidergic System in the Activity.

Authors:  Nazlı Turan Yücel; Derya Osmaniye; Ümmühan Kandemir; Asaf Evrim Evren; Özgür Devrim Can; Ümide Demir Özkay
Journal:  Molecules       Date:  2021-06-02       Impact factor: 4.411

6.  Piperazine- and Piperidine-Containing Thiazolo[5,4-d]pyrimidine Derivatives as New Potent and Selective Adenosine A2A Receptor Inverse Agonists.

Authors:  Flavia Varano; Daniela Catarzi; Erica Vigiani; Fabrizio Vincenzi; Silvia Pasquini; Katia Varani; Vittoria Colotta
Journal:  Pharmaceuticals (Basel)       Date:  2020-07-24

7.  Synthesis and In Vitro Antimycobacterial Activity of Novel N-Arylpiperazines Containing an Ethane-1,2-diyl Connecting Chain.

Authors:  Tomáš Goněc; Ivan Malík; Jozef Csöllei; Josef Jampílek; Jiřina Stolaříková; Ivan Solovič; Peter Mikuš; Stanislava Keltošová; Peter Kollár; Jim O'Mahony; Aidan Coffey
Journal:  Molecules       Date:  2017-11-30       Impact factor: 4.411

8.  eToxPred: a machine learning-based approach to estimate the toxicity of drug candidates.

Authors:  Limeng Pu; Misagh Naderi; Tairan Liu; Hsiao-Chun Wu; Supratik Mukhopadhyay; Michal Brylinski
Journal:  BMC Pharmacol Toxicol       Date:  2019-01-08       Impact factor: 2.483

9.  Design, Synthesis, and Antiproliferative Evaluation of Novel Coumarin/2-Cyanoacryloyl Hybrids as Apoptosis Inducing Agents by Activation of Caspase-Dependent Pathway.

Authors:  Yu-Ying Zhang; Qian-Qian Zhang; Jia-Li Song; Liang Zhang; Cheng-Shi Jiang; Hua Zhang
Journal:  Molecules       Date:  2018-08-07       Impact factor: 4.411

10.  (1-aryloxy-2-hydroxypropyl)-phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition.

Authors:  Shuo Zhao; Jun-Jun Huang; Xiuyun Sun; Xiaorong Huang; Shuna Fu; Liang Yang; Xue-Wei Liu; Fei He; Yinyue Deng
Journal:  Microb Biotechnol       Date:  2018-09-17       Impact factor: 5.813
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.