Jian Ge1, Yuan-Zi Yu1, Tao Li1, Zhao-Yang Guo2, Hao Wu3, Shao-Can Tang4, Xin-Guang Liu5, Qiang Zhu1. 1. Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong University Jing 5 Road, Jinan, P. R. China. 2. Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong University Jing 5 Road, Jinan, P. R. China. 3. Medical School of Shandong University 44 Wenhua Road, Jinan, P. R. China. 4. Department of Physical Medicine and Rehabilitation Physiatry, Shandong Provincial Hospital Affiliated to Shandong University Jing 5 Road, Jinan, P. R. China. 5. Department of Hematology, Qilu Hospital, Shandong University 107 West Wenhua Road, Jinan, P. R. China.
Abstract
BACKGROUND: IL-17A G197A and IL-17F A7488G gene polymorphisms are found to be associated with the risk of several diseases, however few studies have focused on their correlation with risk of liver cirrhosis (LC). AIMS: The aim of this study was to assess the impact of IL-17A G197A and IL-17F A7488G gene polymorphisms on development of LC from chronic hepatitis B (CHB) in Chinese patients. METHODS: A total of 163 HBV-related LC patients and 168 CHB patients were enrolled in the present study. IL-17A and IL-17F gene polymorphisms were analyzed using a polymerase chain reaction (PCR) restriction fragment length polymorphism assay (PCR-RFLP). RESULTS: Frequencies of IL-17A G197A genotype AA and allele A were significantly higher in LC patients compared with that in CHB patients (AA 42.33% vs 27.98%, P = 0.032; A 56.34% vs 46.15%, P=0.011, respectively); While no significant difference in frequencies of genotypes and alleles of IL-17F A7488G was found between the two groups. The AA genotype of IL-17A G197A significantly increased LC risk (OR 4.186, 95% CI: 1.479-11.844), while A allele carriers were also associated with an increased LC risk (OR 1.856, 95% CI: 1.161-2.967). CONCLUSION: IL-17A G197A is a candidate gene that confers the genetic susceptibility for LC development from CHB in Chinese population.
BACKGROUND:IL-17AG197A and IL-17FA7488G gene polymorphisms are found to be associated with the risk of several diseases, however few studies have focused on their correlation with risk of liver cirrhosis (LC). AIMS: The aim of this study was to assess the impact of IL-17AG197A and IL-17FA7488G gene polymorphisms on development of LC from chronic hepatitis B (CHB) in Chinese patients. METHODS: A total of 163 HBV-related LC patients and 168 CHB patients were enrolled in the present study. IL-17A and IL-17F gene polymorphisms were analyzed using a polymerase chain reaction (PCR) restriction fragment length polymorphism assay (PCR-RFLP). RESULTS: Frequencies of IL-17AG197A genotype AA and allele A were significantly higher in LC patients compared with that in CHB patients (AA 42.33% vs 27.98%, P = 0.032; A 56.34% vs 46.15%, P=0.011, respectively); While no significant difference in frequencies of genotypes and alleles of IL-17FA7488G was found between the two groups. The AA genotype of IL-17AG197A significantly increased LC risk (OR 4.186, 95% CI: 1.479-11.844), while A allele carriers were also associated with an increased LC risk (OR 1.856, 95% CI: 1.161-2.967). CONCLUSION:IL-17AG197A is a candidate gene that confers the genetic susceptibility for LC development from CHB in Chinese population.
Authors: Estelle Bettelli; Yijun Carrier; Wenda Gao; Thomas Korn; Terry B Strom; Mohamed Oukka; Howard L Weiner; Vijay K Kuchroo Journal: Nature Date: 2006-04-30 Impact factor: 49.962
Authors: Ainara Castellanos-Rubio; Izortze Santin; Iñaki Irastorza; Luis Castaño; Juan Carlos Vitoria; Jose Ramon Bilbao Journal: Autoimmunity Date: 2009-01 Impact factor: 2.815