Yuying Chen1, Xinli Liu2, Min Chen3, Jian Shen3, Yanqi Lu3, Lei Yu4, Shouying Liu5. 1. Department of Oncology, Jiulongpo District Hospital of Traditional Chinese Medicine in Chongqing City Chongqing, China ; College of Bio-Information, Chongqing University of Posts and Telecommunications Chongqing, China. 2. Department of Obstetrics and Gynecology, 263 Clinical of the General Hospital of Beijing Military Area Beijing 101149, China. 3. Department of Oncology, Jiulongpo District Hospital of Traditional Chinese Medicine in Chongqing City Chongqing, China. 4. Department of Infectious Disease, The Fourth Hospital of Harbin Medical University Harbin 150001, Heilongjiang, China. 5. Department of Orthopedics, 253 Hospital of Chinese PLA Huhhot 010050, China.
Abstract
BACKGROUND: Several molecular epidemiological studies have explored the association between G46295A variant of CD192 gene and cervical cancer susceptibility in distinct populations. However, the results are contradictory. To provide convincing evidence for the association, we performed the present meta-analysis incorporating all case-control studies. METHODS AND FINDINGS: The Cochrane, Google Scholar and PubMed databases were systematically searched to identify the potentially relevant studies. Statistical analyses were performed using R software. Crude odds ratio (OR) was calculated to estimate the risk of cervical cancer. Five case-control studies were considered in the final analysis. Using the homozygous, heterogeneous, allele, dominant, and recessive model, we found the association between CD192 G46295A variant and cervical cancer was not statistically significant. CONCLUSIONS: This meta-analysis shows that the CD192 G46295A variant may not confer genetic susceptibility towards cervical cancer.
BACKGROUND: Several molecular epidemiological studies have explored the association between G46295A variant of CD192 gene and cervical cancer susceptibility in distinct populations. However, the results are contradictory. To provide convincing evidence for the association, we performed the present meta-analysis incorporating all case-control studies. METHODS AND FINDINGS: The Cochrane, Google Scholar and PubMed databases were systematically searched to identify the potentially relevant studies. Statistical analyses were performed using R software. Crude odds ratio (OR) was calculated to estimate the risk of cervical cancer. Five case-control studies were considered in the final analysis. Using the homozygous, heterogeneous, allele, dominant, and recessive model, we found the association between CD192G46295A variant and cervical cancer was not statistically significant. CONCLUSIONS: This meta-analysis shows that the CD192G46295A variant may not confer genetic susceptibility towards cervical cancer.
Authors: A Sica; A Saccani; B Bottazzi; S Bernasconi; P Allavena; B Gaetano; F Fei; G LaRosa; C Scotton; F Balkwill; A Mantovani Journal: J Immunol Date: 2000-01-15 Impact factor: 5.422
Authors: N Polentarutti; P Allavena; G Bianchi; G Giardina; A Basile; S Sozzani; A Mantovani; M Introna Journal: J Immunol Date: 1997-03-15 Impact factor: 5.422
Authors: Vera Levina; Brian M Nolen; Adele M Marrangoni; Peng Cheng; Jeffrey R Marks; Miroslaw J Szczepanski; Marta E Szajnik; Elieser Gorelik; Anna E Lokshin Journal: Clin Cancer Res Date: 2009-04-07 Impact factor: 12.531