Bing Li1, Xin Wang1, Hong Chen2, Li-Xin Shang1, Nan Wu1. 1. Department of Gynecology and Obstetrics, Anhui Medical University Affiliated Military General Hospital of Beijing PLA Cilnical College Beijing 100700, People's Republic of China. 2. Department of Anesthesiology, Anhui Medical University Affiliated Military General Hospital of Beijing PLA Cilnical College Beijing 100700, People's Republic of China.
Abstract
BACKGROUND: Although many epidemiologic studies investigated the TP53 codon 72 polymorphism and its association with cervical cancer (CC), definite conclusions cannot be drawn. AIM OF THE STUDY: To evaluate the association between TP53 codon 72 polymorphism and risk of cervical cancer in the Chinese population. METHODS: A computerized literature search was carried out in PubMed, Springer Link, Ovid, Chinese Biomedical Database (CBM), Chinese National Knowledge Infrastructure (CNKI), and Chinese Wanfang Database to collect relevant articles. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association. RESULTS: A total of 16 studies including 1684 CC cases and 1178 controls were involved in this meta-analysis. Overall, significant increased association was found between the Pro/Pro carriers and CC risk when all studies in Chinese population pooled into the meta-analysis (heterozygous model: OR = 1.22, 95% CI: 1.01-1.46). In subgroup analyses stratified by ethnicity and source of controls, the same results were observed in Han and in hospital-based studies. CONCLUSION: Our results suggest that the TP53 codon 72 polymorphism may be potential biomarkers for CC risk in the Chinese population, especially for Han Chinese, and studies with wider spectrum of population are required for definite conclusions.
BACKGROUND: Although many epidemiologic studies investigated the TP53 codon 72 polymorphism and its association with cervical cancer (CC), definite conclusions cannot be drawn. AIM OF THE STUDY: To evaluate the association between TP53 codon 72 polymorphism and risk of cervical cancer in the Chinese population. METHODS: A computerized literature search was carried out in PubMed, Springer Link, Ovid, Chinese Biomedical Database (CBM), Chinese National Knowledge Infrastructure (CNKI), and Chinese Wanfang Database to collect relevant articles. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association. RESULTS: A total of 16 studies including 1684 CC cases and 1178 controls were involved in this meta-analysis. Overall, significant increased association was found between the Pro/Pro carriers and CC risk when all studies in Chinese population pooled into the meta-analysis (heterozygous model: OR = 1.22, 95% CI: 1.01-1.46). In subgroup analyses stratified by ethnicity and source of controls, the same results were observed in Han and in hospital-based studies. CONCLUSION: Our results suggest that the TP53 codon 72 polymorphism may be potential biomarkers for CC risk in the Chinese population, especially for Han Chinese, and studies with wider spectrum of population are required for definite conclusions.
Authors: F X Bosch; N Muñoz; S de Sanjosé; C Navarro; P Moreo; N Ascunce; L C Gonzalez; L Tafur; M Gili; I Larrañaga Journal: Cancer Epidemiol Biomarkers Prev Date: 1993 Sep-Oct Impact factor: 4.254
Authors: Andrés López-Cortés; Santiago Guerrero; María Ana Redal; Angel Tito Alvarado; Luis Abel Quiñones Journal: Int J Mol Sci Date: 2017-05-23 Impact factor: 5.923