Jun Guo1, Jing Yang2, Yan Li1. 1. Department of Clinical Laboratory, Renmin Hospital of Wuhan University Wuhan 430060, Hubei, China. 2. Department of Microbiology, School of Basic Medical Sciences, Hubei University of Medicine Shiyan 442000, Hubei, China.
Abstract
BACKGROUND: Since, the relationship between hOGG1 Ser326Cys polymorphism and HCC was inconsistent in the recent literatures. The present meta-analysis based on previous studies was to obtain precise estimation on the issue. METHODS: A computer search was carried out from PubMed, CBM and EMBASE databases. A total of nine case-control publications with 2583 HCC patients and 2271 controls were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the relationship of Ser326Cys polymorphism and HCC susceptibility. Z test was used to assess the significance of pooled OR. The fixed-effect model or random-effect model was employed according to heterogeneity. RESULTS: Overall, hOGG1 Ser326Cys polymorphism was in relation with increased risk for HCC under the following genetic models: GG versus CC: OR=2.51, 95% CI=1.67-3.78; GG versus CG + CC: OR=2.27, 95% CI=1.57-3.30; GG + CG versus CC: OR=1.13, 95% CI=1.03-1.24. The subgroup analysis by ethnicity suggested that high risk for HCC was observed in Asians with GG and GG + CG genotype (GG versus CC: OR=2.17, 95% CI=1.49-3.17; GG versus CG + CC: OR=1.96, 95% CI=1.41-2.73; GG + CG versus CC: OR=1.13, 95% CI=1.03-1.25). For subgroup analysis based on source of control, GG genotype of Ser326Cys was significantly associated with HCC risk in hospital-based (HB) controls (GG versus CC: OR=2.31, 95% CI=1.50-3.56; GG versus CG + CC: OR=2.17, 95% CI=1.44-3.28), as well as in population-based (PB) models (GG vs. CC: OR=2.80, 95% CI=1.16-6.77; GG versus CG + CC: OR=2.39, 95% CI=1.08-5.30). CONCLUSIONS: According to the results, hOGG1 Ser326Cys polymorphism was associated with increased risk of HCC.
BACKGROUND: Since, the relationship between hOGG1 Ser326Cys polymorphism and HCC was inconsistent in the recent literatures. The present meta-analysis based on previous studies was to obtain precise estimation on the issue. METHODS: A computer search was carried out from PubMed, CBM and EMBASE databases. A total of nine case-control publications with 2583 HCC patients and 2271 controls were included in the meta-analysis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the relationship of Ser326Cys polymorphism and HCC susceptibility. Z test was used to assess the significance of pooled OR. The fixed-effect model or random-effect model was employed according to heterogeneity. RESULTS: Overall, hOGG1 Ser326Cys polymorphism was in relation with increased risk for HCC under the following genetic models: GG versus CC: OR=2.51, 95% CI=1.67-3.78; GG versus CG + CC: OR=2.27, 95% CI=1.57-3.30; GG + CG versus CC: OR=1.13, 95% CI=1.03-1.24. The subgroup analysis by ethnicity suggested that high risk for HCC was observed in Asians with GG and GG + CG genotype (GG versus CC: OR=2.17, 95% CI=1.49-3.17; GG versus CG + CC: OR=1.96, 95% CI=1.41-2.73; GG + CG versus CC: OR=1.13, 95% CI=1.03-1.25). For subgroup analysis based on source of control, GG genotype of Ser326Cys was significantly associated with HCC risk in hospital-based (HB) controls (GG versus CC: OR=2.31, 95% CI=1.50-3.56; GG versus CG + CC: OR=2.17, 95% CI=1.44-3.28), as well as in population-based (PB) models (GG vs. CC: OR=2.80, 95% CI=1.16-6.77; GG versus CG + CC: OR=2.39, 95% CI=1.08-5.30). CONCLUSIONS: According to the results, hOGG1 Ser326Cys polymorphism was associated with increased risk of HCC.
Entities:
Keywords:
Human 8-oxoguanine glycosylase 1; Ser326Cys; hepatocellular carcinoma; risk