Xiuqin Sun1, Jilin Ying2, Yunan Wang3, Wei Li4, Yaojiang Wu5, Baoting Yao3, Ying Liu3, Hongkai Gao6, Xiaomei Zhang7. 1. Department of Endocrinology and Metabolism, Anzhen Hospital of Beijing Affiliated to Capital Medical University Beijing, China. 2. Department of Orthopedics, Puren Hospital of Beijing China. 3. Department of Endocrinology, The First Hospital of Dandong Liaoning, China. 4. Department of General Surgery, Changhai Hospital Affiliated to The Second Military Medical University Shanghai, China. 5. Department of General Surgery, The First Hospital of Dandong Liaoning, China. 6. Department of General Surgery, General Hospital of Armed Police Beijing, China. 7. Department of Endocrinology and Metabolism, International Hospital of Peking University Beijing, China.
Abstract
AIM: Meta-analysis on the effectiveness of the autologous stem cell transplantation in curing limb ischemic. METHOD: Consulting papers relate to the autologous stem cell transplantation in curing limb ischemic in PubMed, CNKI, Wan-fang Data and VIP. Based on include and exclude standards, we arrange at least 2 evaluators sifting these papers separately, doing Quality evaluation and information extraction and then cross checking. Negotiate through a third party if any disagreement comes out. Review Manager 4.2 is used in Meta-analysis. RESULT: Involved 7 papers, all in English version. Patients involved all diagnosed as critical limb ischemia (CLI). Results show that no adverse reaction occurred during this study. Amputation rate in patients with stem cell group treatment is lower than control group (P < 0.05). And no notable difference in improving ABI (P > 0.05). CONCLUSIONS: Applying autologous stem cell transplantation in curing limb ischemic does not have obviously effectiveness in the improvement of ABI of the limb ischemic patients. But it can dramatically reduce the rate of amputation. So autologous stem cell transplantation is a good and safe choice for patients have no choice but amputation.
AIM: Meta-analysis on the effectiveness of the autologous stem cell transplantation in curing limb ischemic. METHOD: Consulting papers relate to the autologous stem cell transplantation in curing limb ischemic in PubMed, CNKI, Wan-fang Data and VIP. Based on include and exclude standards, we arrange at least 2 evaluators sifting these papers separately, doing Quality evaluation and information extraction and then cross checking. Negotiate through a third party if any disagreement comes out. Review Manager 4.2 is used in Meta-analysis. RESULT: Involved 7 papers, all in English version. Patients involved all diagnosed as critical limb ischemia (CLI). Results show that no adverse reaction occurred during this study. Amputation rate in patients with stem cell group treatment is lower than control group (P < 0.05). And no notable difference in improving ABI (P > 0.05). CONCLUSIONS: Applying autologous stem cell transplantation in curing limb ischemic does not have obviously effectiveness in the improvement of ABI of the limb ischemicpatients. But it can dramatically reduce the rate of amputation. So autologous stem cell transplantation is a good and safe choice for patients have no choice but amputation.
Authors: Mark D Iafrati; John W Hallett; George Geils; Gregory Pearl; Alan Lumsden; Eric Peden; Dennis Bandyk; K S Vijayaraghava; R Radhakrishnan; Enrico Ascher; Anil Hingorani; Sean Roddy Journal: J Vasc Surg Date: 2011-10-21 Impact factor: 4.268
Authors: Michael S Lee; Seung-Woon Rha; Seung Kyu Han; Byoung Geol Choi; Se Yeon Choi; Yoonjee Park; Raghu Akkala; Hu Li; Sung Il Im; Ji Bak Kim; Sunki Lee; Jin Oh Na; Cheol Ung Choi; Hong Euy Lim; Jin Won Kim; Eung Ju Kim; Chang Gyu Park; Hong Seog Seo; Dong Joo Oh Journal: J Invasive Cardiol Date: 2015-04 Impact factor: 2.022
Authors: S Fadilah Abdul Wahid; Nor Azimah Ismail; Wan Fariza Wan Jamaludin; Nor Asiah Muhamad; Muhammad Khairul Azaham Abdul Hamid; Hanafiah Harunarashid; Nai Ming Lai Journal: Cochrane Database Syst Rev Date: 2018-08-29