Literature DB >> 26309070

Rhodium Catalyzed Asymmetric Hydrogenation of 2-Pyridine Ketones.

Hailong Yang1, Ningning Huo1, Ping Yang1, Hao Pei1, Hui Lv1, Xumu Zhang1.   

Abstract

Catalyzed by [Rh(COD)Binapine]BF4, the asymmetric hydrogenation of 2-pyridine ketones has been achieved with excellent enantioselectivities (enantiomeric excesses up to 99%) under mild conditions. This method is suitable for various kinds of 2-pyridine ketones and their derivatives. A number of enantiomerically pure chiral 2-pyridine-aryl/alkyl alcohols were prepared through hydrogenation, which can be used directly in organic synthesis.

Entities:  

Year:  2015        PMID： 26309070     DOI： 10.1021/acs.orglett.5b01878

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  Ruthenium-catalyzed asymmetric hydrogenation of aromatic and heteroaromatic ketones using cinchona alkaloid-derived NNP ligands.

Authors:  Ling Zhang; Qian Chen; Linlin Li; Jian Jiang; Hao Sun; Li Li; Ting Liu; Lin Zhang; Chun Li
Journal:  RSC Adv       Date:  2022-05-18       Impact factor: 4.036

2.  Organocatalytic discrimination of non-directing aryl and heteroaryl groups: enantioselective synthesis of bioactive indole-containing triarylmethanes.

Authors:  Qiaolin Yan; Meng Duan; Cien Chen; Zhiqing Deng; Mandi Wu; Peiyuan Yu; Ming-Liang He; Guangyu Zhu; K N Houk; Jianwei Sun
Journal:  Chem Sci       Date:  2022-04-13       Impact factor: 9.969

3.  Enantiomerically Enriched 1,2-P,N-Bidentate Ferrocenyl Ligands for 1,3-Dipolar Cycloaddition and Transfer Hydrogenation Reactions.

Authors:  Irina A Utepova; Polina O Serebrennikova; Marina S Streltsova; Alexandra A Musikhina; Tatiana G Fedorchenko; Oleg N Chupakhin; Andrey P Antonchick
Journal:  Molecules       Date:  2018-05-30       Impact factor: 4.411

4.  Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow.

Authors:  Xiao-Jing Wei; Timothy Noël
Journal:  J Org Chem       Date:  2018-07-27       Impact factor: 4.354

5.  Hydrogen Atom Transfer Driven Enantioselective Minisci Reaction of Alcohols.

Authors:  Avene C Colgan; Rupert S J Proctor; David C Gibson; Padon Chuentragool; Antti S K Lahdenperä; Kristaps Ermanis; Robert J Phipps
Journal:  Angew Chem Int Ed Engl       Date:  2022-04-27       Impact factor: 16.823
  5 in total

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