| Literature DB >> 26307468 |
Yasunori Kotani1, Yoshimi Ohgami2, Takayuki Ishiwata3, Jun-Ichirou Arai4, Shigeru Kiryu5, Yusuke Inoue6.
Abstract
The stimulus-preceding negativity (SPN) is an event-related potential (ERP) reflecting anticipation. The anterior insular cortex is assumed to be one of the physiological sources of the SPN. However, the precise neural substrates of the SPN have yet to be confirmed. We therefore performed separate functional magnetic resonance imaging (fMRI) and ERP studies using the same time estimation task, followed by fMRI-constrained ERP source analysis. Dipole locations were determined by the fMRI results, while the time courses of dipole activities were modeled by the ERP data. Analysis revealed that the right anterior insula was significantly activated before delivery of the feedback stimulus, whereas the left anterior insula was not, and that the SPN mainly arose from four groups of brain regions related to, respectively: (1) the salience network, (2) reward expectation, (3) perceptual anticipation, and (4) arousal. The results suggest that the SPN pertains to multiple brain functions with complex interactions.Entities:
Keywords: Dipole modeling; Insular cortex; Salience network; Stimulus-preceding negativity
Mesh：
Year: 2015 PMID： 26307468 DOI： 10.1016/j.biopsycho.2015.08.005
Source DB: PubMed Journal: Biol Psychol ISSN： 0301-0511 Impact factor: 3.251