Literature DB >> 26307176

Stable and compact zwitterionic polydiacetylene micelles with tumor-targeting properties.

Ioanna Theodorou1, Parambath Anilkumar, Benoit Lelandais, Damien Clarisse, Anaëlle Doerflinger, Edmond Gravel, Frédéric Ducongé, Eric Doris.   

Abstract

Compact polymerized polydiacetylene-micelles with "stealth" zwitterionic surface coating were assembled and tested in a murine xenograft model of breast cancer. In vivo fluorescence imaging indicated accumulation in the tumor area and histological studies revealed predominant uptake of the micelles at the margins of the tumor, thereby allowing the delineation of its volume.

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Year:  2015        PMID: 26307176     DOI: 10.1039/c5cc05333a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  1 in total

1.  Tuning the cationic interface of simple polydiacetylene micelles to improve siRNA delivery at the cellular level.

Authors:  Minh-Duc Hoang; Marie Vandamme; Gueorgui Kratassiouk; Guillaume Pinna; Edmond Gravel; Eric Doris
Journal:  Nanoscale Adv       Date:  2019-09-24
  1 in total

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