Sébastien Hulo1, Anca Radauceanu2, Nathalie Chérot-Kornobis3, Mike Howsam4, Véronique Vacchina5, Virginie De Broucker6, Davy Rousset7, Michel Grzebyk8, Mathieu Dziurla9, Annie Sobaszek10, Jean-Louis Edme11. 1. Université de Lille: 1, place de Verdun, F-59 000 Lille, France; Faculté de Médecine, Université de Lille 2, EA 4483: 1, place de Verdun, F-59 000 Lille, France; Centre Hospitalier Régional et Universitaire de Lille: 2, avenue Oscar Lambret, 59037 Lille Cedex, France. Electronic address: sebastien.hulo@univ-lille2.fr. 2. Institut National de Recherche et de Sécurité: Rue du Morvan, CS 60027, F-54 519 Vandœuvre-lès-Nancy Cedex, France. Electronic address: anca.radauceanu@inrs.fr. 3. Université de Lille: 1, place de Verdun, F-59 000 Lille, France; Faculté de Médecine, Université de Lille 2, EA 4483: 1, place de Verdun, F-59 000 Lille, France; Centre Hospitalier Régional et Universitaire de Lille: 2, avenue Oscar Lambret, 59037 Lille Cedex, France. Electronic address: nathalie.cherot@univ-lille2.fr. 4. Centre Universitaire de Mesure et d'Analyse, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Lille 2: 3, rue du Professeur Laguesse, BP 83, F-59 006 Lille Cedex, France. Electronic address: michael.howsam@univ-lille2.fr. 5. Ultra Trace Analyse Aquitaine: Technopole Hélioparc, 2 avenue Pierre Angot, F-64 053 Pau Cedex 9, France. Electronic address: veronique.vacchina@univ-pau.fr. 6. Université de Lille: 1, place de Verdun, F-59 000 Lille, France; Faculté de Médecine, Université de Lille 2, EA 4483: 1, place de Verdun, F-59 000 Lille, France; Centre Hospitalier Régional et Universitaire de Lille: 2, avenue Oscar Lambret, 59037 Lille Cedex, France. Electronic address: virginie.debroucker@chru-lille.fr. 7. Institut National de Recherche et de Sécurité: Rue du Morvan, CS 60027, F-54 519 Vandœuvre-lès-Nancy Cedex, France. Electronic address: davy.rousset@inrs.fr. 8. Institut National de Recherche et de Sécurité: Rue du Morvan, CS 60027, F-54 519 Vandœuvre-lès-Nancy Cedex, France. Electronic address: michel.grzebyk@inrs.fr. 9. Institut National de Recherche et de Sécurité: Rue du Morvan, CS 60027, F-54 519 Vandœuvre-lès-Nancy Cedex, France. Electronic address: mathieu.dziurla@inrs.fr. 10. Université de Lille: 1, place de Verdun, F-59 000 Lille, France; Faculté de Médecine, Université de Lille 2, EA 4483: 1, place de Verdun, F-59 000 Lille, France; Centre Hospitalier Régional et Universitaire de Lille: 2, avenue Oscar Lambret, 59037 Lille Cedex, France. Electronic address: annie.sobaszek@univ-lille2.fr. 11. Université de Lille: 1, place de Verdun, F-59 000 Lille, France; Faculté de Médecine, Université de Lille 2, EA 4483: 1, place de Verdun, F-59 000 Lille, France; Centre Hospitalier Régional et Universitaire de Lille: 2, avenue Oscar Lambret, 59037 Lille Cedex, France. Electronic address: jledme@univ-lille2.fr.
Abstract
OBJECTIVE: Low beryllium exposure can induce pulmonary granulomatosis, so called berylliosis. For occupational health monitoring, it is more relevant to assess the internal dose of Be received by the lungs than urinary or atmospheric Be. Exhaled breath condensate (EBC) is a matrix collected non-invasively that derives from the airway lining fluid. EBC beryllium (Be) levels were evaluated as a marker of occupational exposure in a primary aluminum production plant. METHODS: We collected urine and EBC from controls and workers recently exposed to beryllium in the pot room and the anode repair sectors, and calculated a cumulative beryllium exposure index (CBEI) summing the number of years of employment in each task and multiplying by the estimated average beryllium exposure for the task. Concentrations of beryllium and aluminum were measured in EBC (Be-EBC and Al-EBC) and in urine (Be-U and Al-U) by ICP-MS. RESULTS AND CONCLUSION: We have shown that it was possible to measure Be and Al in workers' EBC. Compared with controls and after adjustment for smoking status, levels of Be-EBC and Al-EBC were higher in pot room workers and exposed subjects, respectively. Due to its relationship with CBEI, but not with Be-U, it appears that Be-EBC could be a promising marker of occupational exposure and provide additional toxicokinetic information in occupational health studies.
OBJECTIVE: Low beryllium exposure can induce pulmonary granulomatosis, so called berylliosis. For occupational health monitoring, it is more relevant to assess the internal dose of Be received by the lungs than urinary or atmospheric Be. Exhaled breath condensate (EBC) is a matrix collected non-invasively that derives from the airway lining fluid. EBCberyllium (Be) levels were evaluated as a marker of occupational exposure in a primary aluminum production plant. METHODS: We collected urine and EBC from controls and workers recently exposed to beryllium in the pot room and the anode repair sectors, and calculated a cumulative beryllium exposure index (CBEI) summing the number of years of employment in each task and multiplying by the estimated average beryllium exposure for the task. Concentrations of beryllium and aluminum were measured in EBC (Be-EBC and Al-EBC) and in urine (Be-U and Al-U) by ICP-MS. RESULTS AND CONCLUSION: We have shown that it was possible to measure Be and Al in workers' EBC. Compared with controls and after adjustment for smoking status, levels of Be-EBC and Al-EBC were higher in pot room workers and exposed subjects, respectively. Due to its relationship with CBEI, but not with Be-U, it appears that Be-EBC could be a promising marker of occupational exposure and provide additional toxicokinetic information in occupational health studies.
Authors: Anjoeka Pronk; Miranda Loh; Eelco Kuijpers; Maria Albin; Jenny Selander; Lode Godderis; Manosij Ghosh; Roel Vermeulen; Susan Peters; Ingrid Sivesind Mehlum; Michelle C Turner; Vivi Schlünssen; Marcel Goldberg; Manolis Kogevinas; Barbara N Harding; Svetlana Solovieva; Tina Garani-Papadatos; Martie van Tongeren; Rob Stierum Journal: Environ Epidemiol Date: 2022-02-17