Meiling Gu1, Zhenhua Zhai2, Li Huang3, Wenjiao Zheng4, Yichao Zhou5, Ruiqi Zhu6, Feifei Shen7, Caijun Yuan8. 1. Department of Oncology, The First Affiliated Hospital of Liaoning Medical University, No. 2, The Fifth Section of Renmin Street, Guta, Jinzhou, 121000, Liaoning, China. 2. Department of Oncology Tumour Angiogenesis and Microenvironment Laboratory, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, Liaoning, China. 3. Institute of Biological Anthropology Research, Liaoning Medical University, Jinzhou, 121000, Liaoning, China. 4. Department of Immunology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, Liaoning, China. 5. Department of Breast Surgeon, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, Liaoning, China. 6. Department of Laboratory, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, Liaoning, China. 7. Department of Pathology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, 121000, Liaoning, China. 8. Department of Oncology, The First Affiliated Hospital of Liaoning Medical University, No. 2, The Fifth Section of Renmin Street, Guta, Jinzhou, 121000, Liaoning, China. yuancaijun112@sina.com.
Abstract
BACKGROUND: Mean platelet volume (MPV) is one of the four platelet parameters (platelet count, MPV, platelet distribution width and plateletcrit), which indicates the activation of platelet. We aim to investigate the associations between pre-treatment MPV levels and clinical hematology parameters, pathology parameters and prognosis of patients with invasive breast cancer (IBC). METHODS: Medical records of 340 breast tumor patients (170 IBC vs. 170 breast benign tumor) were retrospectively reviewed. Patients in two groups were matched for age, body mass index, smoking status and complications. To analyze: differences in pre-treatment MPV levels between IBC group and breast benign tumor group; differences between pre- and postoperative MPV levels in IBC patients; correlations between pre-treatment MPV and clinical hematology parameters, clinicopathologic parameters and prognosis in IBC patients. RESULTS: As we analyzed, pre-treatment MPV levels of IBC patients were significantly higher than the controls (8.65 ± 0.98 vs 8.34 ± 0.78, P = 0.002), and preoperative MPV levels were significantly higher than the postoperative in IBC patients (8.65 ± 0.98 vs 8.44 ± 0.91, P = 0.042). In IBC group, pre-treatment MPV level associated, significantly, with clinical hematology parameters (platelet, fibrinogen, albumin, fasting blood glucose, P = 0.003, 0.042, 0.032, 0.046, respectively) and with clinicopathological parameters (distant metastasis, primary tumor size, tumor node metastasis stages, P = 0.039, 0.002, 0.001, respectively). Furthermore, univariate and multivariate survival analysis demonstrated that MPV was significant prognostic factor (P = 0.035, HR 1.86, 95 % confidence interval 1.06-3.25). CONCLUSION: High pre-treatment MPV level in IBC patients was a potential predictive factor and significant independent prognostic factor.
BACKGROUND: Mean platelet volume (MPV) is one of the four platelet parameters (platelet count, MPV, platelet distribution width and plateletcrit), which indicates the activation of platelet. We aim to investigate the associations between pre-treatment MPV levels and clinical hematology parameters, pathology parameters and prognosis of patients with invasive breast cancer (IBC). METHODS: Medical records of 340 breast tumorpatients (170 IBC vs. 170 breast benign tumor) were retrospectively reviewed. Patients in two groups were matched for age, body mass index, smoking status and complications. To analyze: differences in pre-treatment MPV levels between IBC group and breast benign tumor group; differences between pre- and postoperative MPV levels in IBCpatients; correlations between pre-treatment MPV and clinical hematology parameters, clinicopathologic parameters and prognosis in IBCpatients. RESULTS: As we analyzed, pre-treatment MPV levels of IBCpatients were significantly higher than the controls (8.65 ± 0.98 vs 8.34 ± 0.78, P = 0.002), and preoperative MPV levels were significantly higher than the postoperative in IBCpatients (8.65 ± 0.98 vs 8.44 ± 0.91, P = 0.042). In IBC group, pre-treatment MPV level associated, significantly, with clinical hematology parameters (platelet, fibrinogen, albumin, fasting blood glucose, P = 0.003, 0.042, 0.032, 0.046, respectively) and with clinicopathological parameters (distant metastasis, primary tumor size, tumor node metastasis stages, P = 0.039, 0.002, 0.001, respectively). Furthermore, univariate and multivariate survival analysis demonstrated that MPV was significant prognostic factor (P = 0.035, HR 1.86, 95 % confidence interval 1.06-3.25). CONCLUSION: High pre-treatment MPV level in IBCpatients was a potential predictive factor and significant independent prognostic factor.
Entities:
Keywords:
Invasive breast cancer; Mean platelet volume; Predictive factor; Prognostic factor