| Literature DB >> 26306453 |
Giovanni Caocci1, Bruno Martino2, Marianna Greco3, Elisabetta Abruzzese4, Malgorzata Monika Trawinska4, Sara Lai5, Paola Ragatzu5, Sara Galimberti6, Claudia Baratè6, Olga Mulas3, Claudia Labate2, Roberto Littera5, Carlo Carcassi5, Carlo Gambacorti Passerini7, Giorgio La Nasa3.
Abstract
Several factors are predictive of treatment-free remission (TFR) in chronic myeloid leukemia (CML), but few data exist on the role of natural killer (NK) cells and their killer-cell immunoglobulin-like receptors (KIRs). KIR and human leukocyte antigen (HLA) genotypes were investigated in 36 CML patients who discontinued tyrosine kinase inhibitor (TKI) treatment after achieving deep molecular response (MR(4.5)). Cumulative TFR was significantly higher in patients homozygous for KIR A haplotype (85.7% vs. 45.5%; p = 0.029). Younger age, Bx haplotype, and the combination KIR3DS1/KIR3DL1 present/HLA-Bw4 present were significantly associated with relapse. KIR genotypes could prove useful in identifying patients that are likely to maintain MR(4.5) after discontinuing TKI treatment.Entities:
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Year: 2015 PMID： 26306453 DOI： 10.1016/j.exphem.2015.08.004
Source DB: PubMed Journal: Exp Hematol ISSN： 0301-472X Impact factor: 3.084