| Literature DB >> 26305520 |
Bruce D Levy1, Patricia J Noel2, Michelle M Freemer2, Michelle M Cloutier3, Steve N Georas4, Nizar N Jarjour5, Carole Ober6, Prescott G Woodruff7, Kathleen C Barnes8, Bruce G Bender9, Carlos A Camargo10, Geoff L Chupp11, Loren C Denlinger5, John V Fahy7, Anne M Fitzpatrick12, Anne Fuhlbrigge1, Ben M Gaston13, Tina V Hartert14, Jay K Kolls15, Susan V Lynch7, Wendy C Moore16, Wayne J Morgan17, Kari C Nadeau18, Dennis R Ownby19, Julian Solway6, Stanley J Szefler20, Sally E Wenzel15, Rosalind J Wright21, Robert A Smith2, Serpil C Erzurum22.
Abstract
Asthma is a common chronic disease without cure. Our understanding of asthma onset, pathobiology, classification, and management has evolved substantially over the past decade; however, significant asthma-related morbidity and excess healthcare use and costs persist. To address this important clinical condition, the NHLBI convened a group of extramural investigators for an Asthma Research Strategic Planning workshop on September 18-19, 2014, to accelerate discoveries and their translation to patients. The workshop focused on (1) in utero and early-life origins of asthma, (2) the use of phenotypes and endotypes to classify disease, (3) defining disease modification, (4) disease management, and (5) implementation research. This report summarizes the workshop and produces recommendations to guide future research in asthma.Entities:
Keywords: asthma; disease modification; implementation; phenotype; prevention
Mesh：
Year: 2015 PMID： 26305520 PMCID： PMC4731702 DOI： 10.1164/rccm.201505-0963WS
Source DB: PubMed Journal: Am J Respir Crit Care Med ISSN： 1073-449X Impact factor: 21.405