Literature DB >> 26304958

Ambulatory Aortic Stiffness Is Associated With Narrow Retinal Arteriolar Caliber in Hypertensives: The SAFAR Study.

Evaggelia K Aissopou1, Antoniοs A Argyris2, Efthimia G Nasothimiou2, George D Konstantonis2, Kostas Tampakis2, Nikolaos Tentolouris2, Miltiadis Papathanassiou3, Panagiotis G Theodossiadis3, Theodoros G Papaioannou4, Coen D A Stehouwer5, Petros P Sfikakis2, Athanassios D Protogerou6.   

Abstract

BACKGROUND: Arterial stiffness measured under static conditions reclassifies significantly cardiovascular (CV) risk and associates with narrower retinal arterioles. However, arterial stiffness exhibits circadian variation, thus single static stiffness recordings do not correspond to the "usual" 24 hr, awake, and asleep average arterial stiffness. We aimed to test the hypothesis that ambulatory 24 hr, awake, and asleep aortic (a) pulse wave velocity (PWV) associate with retinal vessel calibers, independently of confounders and of static arterial stiffness, in hypertensive individuals free from diabetes and CV disease.
METHODS: Digital retinal images were obtained (181 individuals, age: 53.9±10.7 years, 55.2% men) and retinal vessel calibers were measured with validated software to determine central retinal arteriolar and venular equivalents (CRAE and CRVE, respectively); ambulatory (24 hr, awake, asleep) and static office aPWV were estimated by Mobil-O-Graph; and static office carotid to femoral (cf) PWV by SphygmoCor.
RESULTS: Regression analysis performed in 320 gradable retinal images showed that, after adjustment for confounders: (i) ambulatory aPWV was significantly associated with narrower retinal arterioles but not with venules; (ii) asleep aPWV had stronger associations with CRAE than awake aPWV; (iii) both ambulatory aPWV and cfPWV were associated mutually independently with narrower retinal arterioles; aPWV introduction in the model of cfPWV, improved model's R2 (P = 0.012). Similar discriminatory ability of 24 hr aPWV and of cfPWV to detect the presence of retinal arteriolar narrowing was found.
CONCLUSION: Ambulatory aPWV, estimated by an operator-independent method, provides additional information to cfPWV regarding the associations of arterial stiffness with the retinal vessel calibers. © American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Entities:  

Keywords:  ambulatory arterial stiffness; arterial distensibility; blood pressure; hypertension; pulse wave velocity; retinal arterioles; retinal venules.

Mesh：

Year:  2015        PMID： 26304958     DOI： 10.1093/ajh/hpv145

Source DB:  PubMed          Journal:  Am J Hypertens        ISSN： 0895-7061            Impact factor:   2.689


  10 in total

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Authors:  Stefano Omboni; Igor N Posokhov; Yulia V Kotovskaya; Athanase D Protogerou; Jacques Blacher
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6.  Correlation between office and 24-hour ambulatory measures of pulse wave velocity, central augmentation index and central blood pressure.

Authors:  Annelise M G Paiva; Andréa A Brandão; Audes D M Feitosa; Gabriela C A Novais; Emanuelle M Cantarelli; Maria Inês C M Gomes; Camila L D M Feitosa; Andrei C Sposito; Wilson Nadruz; Marco A Mota-Gomes
Journal:  J Clin Hypertens (Greenwich)       Date:  2019-01-28       Impact factor: 3.738

7.  Vascular Health Assessment of The Hypertensive Patients (VASOTENS) Registry: Study Protocol of an International, Web-Based Telemonitoring Registry for Ambulatory Blood Pressure and Arterial Stiffness.

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9.  Effect of Nebivolol and Olmesartan on 24-Hour Brachial and Aortic Blood Pressure in the Acute Stage of Ischemic Stroke.

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10.  Central arterial stiffness and retinal vessel calibers: the Atherosclerosis Risk in Communities Study-Neurocognitive Study.

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Journal:  J Hypertens       Date:  2020-02       Impact factor: 4.776
  10 in total

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