BACKGROUND: As the second leading cause of death and the leading cause of adult-onset disability, stroke is a major public health concern particularly pertinent in Sub-Saharan Africa (SSA), where nearly 80% of all global stroke mortalities occur, and stroke burden is projected to increase in the coming decades. However, traditional and emerging risk factors for stroke in SSA have not been well characterized, thus limiting efforts at curbing its devastating toll. The Stroke Investigative Research and Education Network (SIREN) project is aimed at comprehensively evaluating the key environmental and genomic risk factors for stroke (and its subtypes) in SSA while simultaneously building capacities in phenomics, biobanking, genomics, biostatistics, and bioinformatics for brain research. METHODS: SIREN is a transnational, multicentre, hospital and community-based study involving 3,000 cases and 3,000 controls recruited from 8 sites in Ghana and Nigeria. Cases will be hospital-based patients with first stroke within 10 days of onset in whom neurovascular imaging will be performed. Etiological and topographical stroke subtypes will be documented for all cases. Controls will be hospital- and community-based participants, matched to cases on the basis of gender, ethnicity, and age (±5 years). Information will be collected on known and proposed emerging risk factors for stroke. STUDY SIGNIFICANCE: SIREN is the largest study of stroke in Africa to date. It is anticipated that it will shed light on the phenotypic characteristics and risk factors of stroke and ultimately provide evidence base for strategic interventions to curtail the burgeoning burden of stroke on the sub-continent.
BACKGROUND: As the second leading cause of death and the leading cause of adult-onset disability, stroke is a major public health concern particularly pertinent in Sub-Saharan Africa (SSA), where nearly 80% of all global stroke mortalities occur, and stroke burden is projected to increase in the coming decades. However, traditional and emerging risk factors for stroke in SSA have not been well characterized, thus limiting efforts at curbing its devastating toll. The Stroke Investigative Research and Education Network (SIREN) project is aimed at comprehensively evaluating the key environmental and genomic risk factors for stroke (and its subtypes) in SSA while simultaneously building capacities in phenomics, biobanking, genomics, biostatistics, and bioinformatics for brain research. METHODS: SIREN is a transnational, multicentre, hospital and community-based study involving 3,000 cases and 3,000 controls recruited from 8 sites in Ghana and Nigeria. Cases will be hospital-based patients with first stroke within 10 days of onset in whom neurovascular imaging will be performed. Etiological and topographical stroke subtypes will be documented for all cases. Controls will be hospital- and community-based participants, matched to cases on the basis of gender, ethnicity, and age (±5 years). Information will be collected on known and proposed emerging risk factors for stroke. STUDY SIGNIFICANCE: SIREN is the largest study of stroke in Africa to date. It is anticipated that it will shed light on the phenotypic characteristics and risk factors of stroke and ultimately provide evidence base for strategic interventions to curtail the burgeoning burden of stroke on the sub-continent.
Authors: Virginia J Howard; Mary Cushman; Leavonne Pulley; Camilo R Gomez; Rodney C Go; Ronald J Prineas; Andra Graham; Claudia S Moy; George Howard Journal: Neuroepidemiology Date: 2005-06-29 Impact factor: 3.282
Authors: J F Meschia; T G Brott; F E Chukwudelunzu; J Hardy; R D Brown; I Meissner; L J Hall; E J Atkinson; P C O'Brien Journal: Stroke Date: 2000-05 Impact factor: 7.914
Authors: T Truelsen; P U Heuschmann; R Bonita; G Arjundas; P Dalal; A Damasceno; D Nagaraja; A Ogunniyi; S Oveisgharan; K Radhakrishnan; V I Skvortsoya; V Stakhovskaya Journal: Lancet Neurol Date: 2007-02 Impact factor: 44.182
Authors: Mayowa O Owolabi; Onoja M Akpa; Felix Made; Sally N Adebamowo; Akinlolu Ojo; Dwomoa Adu; Ayesha A Motala; Bongani M Mayosi; Bruce Ovbiagele; Clement Adebamowo; Bamidele Tayo; Charles Rotimi; Rufus Akinyemi; Mulugeta Gebregziabher; Fred Sarfo; Kolawole W Wahab; Rulan S Parekh; Mark E Engel; Chisala Chisala; Emmanuel Peprah; George Mensah; Ken Wiley; Jennifer Troyer; Michèle Ramsay Journal: Int J Epidemiol Date: 2019-04-01 Impact factor: 7.196
Authors: Fred Stephen Sarfo; Ohene Opare-Sem; Martin Agyei; John Akassi; Dorcas Owusu; Mayowa Owolabi; Bruce Ovbiagele Journal: J Neurol Sci Date: 2018-09-20 Impact factor: 3.181
Authors: Fred Stephen Sarfo; John Akassi; Sheila Adamu; Vida Obese; Bruce Ovbiagele Journal: J Stroke Cerebrovasc Dis Date: 2017-06-23 Impact factor: 2.136
Authors: Michèle Ramsay; Mayowa O Owolabi; Onoja M Akpa; Felix Made; Akinlolu Ojo; Bruce Ovbiagele; Dwomoa Adu; Ayesha A Motala; Bongani M Mayosi; Sally N Adebamowo; Mark E Engel; Bamidele Tayo; Charles Rotimi; Babatunde Salako; Rufus Akinyemi; Mulugeta Gebregziabher; Fred Sarfo; Kolawole Wahab; Godfred Agongo; Marianne Alberts; Stuart A Ali; Gershim Asiki; Romuald P Boua; F Xavier Gómez-Olivé; Felistas Mashinya; Lisa Micklesfield; Shukri F Mohamed; Engelbert A Nonterah; Shane A Norris; Hermann Sorgho; Stephen Tollman; Rulan S Parekh; Chishala Chishala; Kenneth Ekoru; Salina P Waddy; Emmanuel Peprah; George A Mensah; Ken Wiley; Jennifer Troyer Journal: Hypertension Date: 2020-03-16 Impact factor: 10.190