Mathilde Boulanger1, Fabrice Morlais2, Véronique Bouvier3, Françoise Galateau-Salle4, Lydia Guittet5, Marie-France Marquignon6, Christophe Paris7, Claude Raffaelli8, Guy Launoy9, Bénédicte Clin1. 1. Service de santé au travail et pathologie professionnelle, CHU Caen, Caen, France INSERM, UMR 1086, Cancers et Populations, Caen, France Faculté de Médecine, Université de Caen, Caen, France. 2. INSERM, UMR 1086, Cancers et Populations, Caen, France. 3. Registre des tumeurs digestives du Calvados, Caen, France. 4. Service d'anatomopathologie, CHU Caen, Caen, France. 5. INSERM, UMR 1086, Cancers et Populations, Caen, France Faculté de Médecine, Université de Caen, Caen, France. 6. Service de santé au travail et pathologie professionnelle, CHU Caen, Caen, France. 7. EA7298 INGRES, Nancy, France CHU Nancy, Nancy, France Faculté de Médecine, Université de Lorraine, Nancy, France. 8. Service de Santé au travail, GISTAF, Condé-sur-Noireau, France. 9. INSERM, UMR 1086, Cancers et Populations, Caen, France Faculté de Médecine, Université de Caen, Caen, France Registre des tumeurs digestives du Calvados, Caen, France.
Abstract
OBJECTIVE: The aim of our study was to estimate the incidence of digestive cancers within a cohort of asbestos-exposed workers. METHODS: Our study was based on a cohort of 2024 participants occupationally exposed to asbestos. The incidence of digestive cancers was calculated from 1 January 1978 to 31 December 2009 and compared with levels among the local general population using Standardised Incidence Ratios (SIRs). Asbestos exposure was assessed using the company's job-exposure matrix. RESULTS: 119 cases of digestive cancer were observed within our cohort, for an expected number of 77 (SIR=1.54 (1.28 to 1.85)). A significantly elevated incidence was observed for peritoneal mesothelioma, particularly in women. Significantly elevated incidences were also observed among men for: all digestive cancers, even when excluding peritoneal mesothelioma (SIR=1.50 (1.23 to 1.82)), oesophageal cancer (SIR=1.67 (1.08 to 2.47)) and liver cancer (SIR=1.85 (1.09 to 2.92)). Concerning colorectal cancer, a significant excess of risk was observed for men with exposure duration above 25 years (SIR=1.75 (1.05 to 2.73)). CONCLUSIONS: Our results are in favour of a link between long-duration asbestos exposure and colorectal cancer in men. They also suggest a relationship between asbestos exposure and cancer of the oesophagus in men. Finally, our results suggest a possible association with small intestine and liver cancers in men. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
OBJECTIVE: The aim of our study was to estimate the incidence of digestive cancers within a cohort of asbestos-exposed workers. METHODS: Our study was based on a cohort of 2024 participants occupationally exposed to asbestos. The incidence of digestive cancers was calculated from 1 January 1978 to 31 December 2009 and compared with levels among the local general population using Standardised Incidence Ratios (SIRs). Asbestos exposure was assessed using the company's job-exposure matrix. RESULTS: 119 cases of digestive cancer were observed within our cohort, for an expected number of 77 (SIR=1.54 (1.28 to 1.85)). A significantly elevated incidence was observed for peritoneal mesothelioma, particularly in women. Significantly elevated incidences were also observed among men for: all digestive cancers, even when excluding peritoneal mesothelioma (SIR=1.50 (1.23 to 1.82)), oesophageal cancer (SIR=1.67 (1.08 to 2.47)) and liver cancer (SIR=1.85 (1.09 to 2.92)). Concerning colorectal cancer, a significant excess of risk was observed for men with exposure duration above 25 years (SIR=1.75 (1.05 to 2.73)). CONCLUSIONS: Our results are in favour of a link between long-duration asbestos exposure and colorectal cancer in men. They also suggest a relationship between asbestos exposure and cancer of the oesophagus in men. Finally, our results suggest a possible association with small intestine and liver cancers in men. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
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