Jennifer L Williams1, Andrew H Nguyen2, Matthew Rochefort2, V Raman Muthusamy3, Zev A Wainberg3, David W Dawson4, James S Tomlinson2, O Joe Hines2, Howard A Reber2, Timothy R Donahue2,5. 1. Department of Surgery, Harbor-UCLA Medical Center, Torrance, California. 2. Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California. 3. Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California. 4. Department of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, California. 5. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California.
Abstract
BACKGROUND: Lymph node (LN) involvement is a well-known poor prognostic factor in patients with pancreatic ductal adenocarcinoma (PDAC). However, there have been conflicting results on the significance of the mechanism of LN involvement, "direct" tumor invasion versus "metastatic," disease on patient survival. METHODS: Clinicopathologic records from all patients who underwent resection for PDAC from 1990 to 2014 at a single-institution were reviewed. RESULTS: Of the 385 total patients, there was tumor invasion outside of the pancreas in 289 (75.1%) patients. Overall, 239 (62.1%) had node-positive disease: 220 (92.0%) by "metastatic" involvement, 14 (5.9%) by "direct" tumor extension, and five (2.1%) by a mix of "metastatic" and "direct". There were no significant differences in clinicopathologic factors associated with PDAC survival between "metastatic" and "direct" LN patients. The median overall survival for the whole cohort was 31.1 months. Compared to overall survival in patients with LN-negative disease (median 40.7 months), those with LNs involved by "metastatic" spread was significantly shorter (median 25.7 months, P < 0.001), yet "direct" LN extension was similar (median 48.1 months, P = 0.719). CONCLUSIONS: The mechanism of LN involvement affects PDAC prognosis. Patients with LNs involved by direct extension have similar survival to those with node-negative disease.
BACKGROUND: Lymph node (LN) involvement is a well-known poor prognostic factor in patients with pancreatic ductal adenocarcinoma (PDAC). However, there have been conflicting results on the significance of the mechanism of LN involvement, "direct" tumor invasion versus "metastatic," disease on patient survival. METHODS: Clinicopathologic records from all patients who underwent resection for PDAC from 1990 to 2014 at a single-institution were reviewed. RESULTS: Of the 385 total patients, there was tumor invasion outside of the pancreas in 289 (75.1%) patients. Overall, 239 (62.1%) had node-positive disease: 220 (92.0%) by "metastatic" involvement, 14 (5.9%) by "direct" tumor extension, and five (2.1%) by a mix of "metastatic" and "direct". There were no significant differences in clinicopathologic factors associated with PDAC survival between "metastatic" and "direct" LN patients. The median overall survival for the whole cohort was 31.1 months. Compared to overall survival in patients with LN-negative disease (median 40.7 months), those with LNs involved by "metastatic" spread was significantly shorter (median 25.7 months, P < 0.001), yet "direct" LN extension was similar (median 48.1 months, P = 0.719). CONCLUSIONS: The mechanism of LN involvement affects PDAC prognosis. Patients with LNs involved by direct extension have similar survival to those with node-negative disease.
Authors: Fiona Speichinger; Mihnea P Dragomir; Simon Schallenberg; Florian N Loch; Claudius E Degro; Ann-Kathrin Baukloh; Lisa Hartmann; Ioannis Pozios; Christian Schineis; Georgios Antonios Margonis; Johannes C Lauscher; Katharina Beyer; Carsten Kamphues Journal: Cancers (Basel) Date: 2021-12-31 Impact factor: 6.639
Authors: Eline Soer; Lodewijk Brosens; Marc van de Vijver; Frederike Dijk; Marie-Louise van Velthuysen; Arantza Farina-Sarasqueta; Hans Morreau; Johan Offerhaus; Lianne Koens; Joanne Verheij Journal: Virchows Arch Date: 2018-03-27 Impact factor: 4.064