Vivian P Lara1, Paulo Caramelli2, Antônio L Teixeira2, Maira T Barbosa2, Karoline C Carmona2, Henrique C Guimarães2, Maria G Carvalho1, Ana P Fernandes1, Karina B Gomes3. 1. Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 2. Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. 3. Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. karinabgb@gmail.com.
Abstract
BACKGROUND: Population aging is a global phenomenon whose main consequence is the increase of chronic degenerative diseases, including dementia. The aim of this case-control study was to evaluate the laboratorial parameters lipid profile, cortisol, and apolipoprotein E (APOE) gene genotype, comparing cognitively healthy controls and subjects with cognitive impairment no dementia (CIND) and dementia in a group of elderly people. METHODS: Three hundred and nine individuals enrolled in the Pietà Study (Brazil) were divided into three groups: control (n = 158), CIND (n = 92), and dementia (n = 59). Participants were interviewed, went through examination, and had blood samples taken. RESULTS: Age and APOE showed significant differences among the groups, while sex and lipid profile did not. According to multivariate regression logistic analyses, higher cortisol levels, lower high-density lipoprotein (HDL-c) and very low-density lipoprotein (VLDL-c), presence of ε4 allele of APOE, and aging were associated with CIND and dementia. CONCLUSION: These laboratorial parameters are risk factors associated to CIND and dementia in the elderly people and should be investigated in order to develop strategies to prevent or delay the onset of dementia in the oldest-old populations.
BACKGROUND: Population aging is a global phenomenon whose main consequence is the increase of chronic degenerative diseases, including dementia. The aim of this case-control study was to evaluate the laboratorial parameters lipid profile, cortisol, and apolipoprotein E (APOE) gene genotype, comparing cognitively healthy controls and subjects with cognitive impairment no dementia (CIND) and dementia in a group of elderly people. METHODS: Three hundred and nine individuals enrolled in the Pietà Study (Brazil) were divided into three groups: control (n = 158), CIND (n = 92), and dementia (n = 59). Participants were interviewed, went through examination, and had blood samples taken. RESULTS: Age and APOE showed significant differences among the groups, while sex and lipid profile did not. According to multivariate regression logistic analyses, higher cortisol levels, lower high-density lipoprotein (HDL-c) and very low-density lipoprotein (VLDL-c), presence of ε4 allele of APOE, and aging were associated with CIND and dementia. CONCLUSION: These laboratorial parameters are risk factors associated to CIND and dementia in the elderly people and should be investigated in order to develop strategies to prevent or delay the onset of dementia in the oldest-old populations.
Authors: Serge Gauthier; Barry Reisberg; Michael Zaudig; Ronald C Petersen; Karen Ritchie; Karl Broich; Sylvie Belleville; Henry Brodaty; David Bennett; Howard Chertkow; Jeffrey L Cummings; Mony de Leon; Howard Feldman; Mary Ganguli; Harald Hampel; Philip Scheltens; Mary C Tierney; Peter Whitehouse; Bengt Winblad Journal: Lancet Date: 2006-04-15 Impact factor: 79.321
Authors: M Bonarek; P Barberger-Gateau; L Letenneur; V Deschamps; A Iron; B Dubroca; J F Dartigues Journal: Neuroepidemiology Date: 2000 May-Jun Impact factor: 3.282
Authors: P Caramelli; R Nitrini; R Maranhão; A C Lourenço; M C Damasceno; C Vinagre; B Caramelli Journal: Acta Neurol Scand Date: 1999-07 Impact factor: 3.209
Authors: Eric van Exel; Anton J M de Craen; Jacobijn Gussekloo; Peter Houx; Annetje Bootsma-van der Wiel; Peter W Macfarlane; Gerard J Blauw; Rudi G J Westendorp Journal: Ann Neurol Date: 2002-06 Impact factor: 10.422
Authors: Raj N Kalaria; Gladys E Maestre; Raul Arizaga; Robert P Friedland; Doug Galasko; Kathleen Hall; José A Luchsinger; Adesola Ogunniyi; Elaine K Perry; Felix Potocnik; Martin Prince; Robert Stewart; Anders Wimo; Zhen-Xin Zhang; Piero Antuono Journal: Lancet Neurol Date: 2008-07-28 Impact factor: 44.182
Authors: L A Farrer; L A Cupples; J L Haines; B Hyman; W A Kukull; R Mayeux; R H Myers; M A Pericak-Vance; N Risch; C M van Duijn Journal: JAMA Date: 1997 Oct 22-29 Impact factor: 56.272
Authors: Juho Tynkkynen; Vincent Chouraki; Sven J van der Lee; Jussi Hernesniemi; Qiong Yang; Shuo Li; Alexa Beiser; Martin G Larson; Katri Sääksjärvi; Martin J Shipley; Archana Singh-Manoux; Robert E Gerszten; Thomas J Wang; Aki S Havulinna; Peter Würtz; Krista Fischer; Ayse Demirkan; M Arfan Ikram; Najaf Amin; Terho Lehtimäki; Mika Kähönen; Markus Perola; Andres Metspalu; Antti J Kangas; Pasi Soininen; Mika Ala-Korpela; Ramachandran S Vasan; Mika Kivimäki; Cornelia M van Duijn; Sudha Seshadri; Veikko Salomaa Journal: Alzheimers Dement Date: 2018-03-06 Impact factor: 21.566