OBJECTIVE: To investigate the expression and prognostic value of miR-224 expression in patients with diffuse large B-cell lymphoma (DLBCL) who underwent R-CHOP. MATERIALS AND METHODS: RT-PCR was used to determine the relative expression of miR-224, in 258 DLBCL patients and 40 normal lymphoid tissue specimens. RESULTS: MiR-224 expression in DLBCL patients was significantly down-regulated compared to that in negative controls (p < 0.05). The 5-year progression-free survival and overall survival rates were significantly higher in the high-expression level group compared to the low-expression level group (p < 0.05). CONCLUSIONS: MiR-224 expression level is implicated as a prognostic marker for DLBCL patients treated with R-CHOP.
OBJECTIVE: To investigate the expression and prognostic value of miR-224 expression in patients with diffuse large B-cell lymphoma (DLBCL) who underwent R-CHOP. MATERIALS AND METHODS: RT-PCR was used to determine the relative expression of miR-224, in 258 DLBCL patients and 40 normal lymphoid tissue specimens. RESULTS:MiR-224 expression in DLBCL patients was significantly down-regulated compared to that in negative controls (p < 0.05). The 5-year progression-free survival and overall survival rates were significantly higher in the high-expression level group compared to the low-expression level group (p < 0.05). CONCLUSIONS:MiR-224 expression level is implicated as a prognostic marker for DLBCL patients treated with R-CHOP.
Entities:
Keywords:
Biomarkers; R-CHOP; diffuse large B-cell lymphoma; microRNA
Authors: Giorgio Malpeli; Stefano Barbi; Gabriele Tosadori; Corinna Greco; Simonetta Zupo; Serena Pedron; Matteo Brunelli; Anna Bertolaso; Maria Teresa Scupoli; Mauro Krampera; Paul Takam Kamga; Carlo Maria Croce; George Adrian Calin; Aldo Scarpa; Alberto Zamò Journal: Oncotarget Date: 2018-07-03