Literature DB >> 2630095

Isolation of inhibitors of adenylate cyclase from dan-shen, the root of Salvia miltiorrhiza.

H Kohda, O Takeda, S Tanaka, K Yamasaki, A Yamashita, T Kurokawa, S Ishibashi.   

Abstract

The effect of dan-shen extract, the root of Salvia miltiorrhiza, on adenylate cyclase was investigated in both rat brain and rat erythrocytes. The EtOAc fraction of the MeOH extract was proved to have significant inhibitory activity. Potent inhibitory principles in the EtOAc fraction were isolated and identified as 4 polyphenolic acids, rosemarinic acid, lithospermic acid, and their methyl ester derivatives.

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Year:  1989        PMID: 2630095     DOI: 10.1248/cpb.37.1287

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  4 in total

1.  Antinociceptive activity and effect of methanol extracts of three salvia spp. On withdrawal syndrome in mice.

Authors:  Mohammad Karami; Mohammad Mehdi Shamerani; Ebrahim Hossini; Ahmad Reza Gohari; Mohammad Ali Ebrahimzadeh; Anahita Nosrati
Journal:  Adv Pharm Bull       Date:  2013-08-20

2.  A novel Na+ channel agonist, dimethyl lithospermate B, slows Na+ current inactivation and increases action potential duration in isolated rat ventricular myocytes.

Authors:  Jin-Young Yoon; Sung-Hun Ahn; Hyuncheol Oh; Young-Sup Kim; Shi Yong Ryu; Won-Kyung Ho; Suk-Ho Lee
Journal:  Br J Pharmacol       Date:  2004-10-25       Impact factor: 8.739

3.  Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome.

Authors:  Jeffrey M Fish; Daniel R Welchons; Young-Sup Kim; Suk-Ho Lee; Won-Kyung Ho; Charles Antzelevitch
Journal:  Circulation       Date:  2006-03-13       Impact factor: 29.690

4.  Anti-hepatitis, antioxidant activities and bioactive compounds of Dracocephalum heterophyllum extracts.

Authors:  Qiang-Qiang Shi; Jun Dang; Huai-Xiu Wen; Xiang Yuan; Yan-Duo Tao; Qi-Lan Wang
Journal:  Bot Stud       Date:  2016-08-06       Impact factor: 2.787

  4 in total

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