Literature DB >> 26300547

MicroRNA regulation of the major drug-metabolizing enzymes and related transcription factors.

Douglas F Dluzen1, Philip Lazarus2.   

Abstract

Identifying novel mechanisms contributing to patient variability of drug response is a major goal of personalized medicine. Epigenetic regulation of gene expression by microRNA (miRNA) impacts a broad range of cellular processes, but knowledge of its regulation of drug-metabolizing enzymes (DMEs) is more limited. This review provides an introduction to miRNA and their functionality and summarizes known miRNA regulation of DME families, including the cytochrome P450s, UDP-glucuronoslytransferases, glutathione-S-transferases, sulfotransferases and aldo-keto reductases, and the transcription factors known to be involved in DME regulation.

Entities:  

Keywords:  epigenetic regulation; metabolizing enzymes; miRNA; phase I metabolism; phase II metabolism; transcription factors

Mesh：

Substances：

Year:  2015        PMID： 26300547      PMCID： PMC6309899          DOI： 10.3109/03602532.2015.1076438

Source DB:  PubMed          Journal:  Drug Metab Rev        ISSN： 0360-2532            Impact factor:   4.518


  14 in total

1.  Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes.

Authors:  Stephan C Jahn; Lauren A Gay; Claire J Weaver; Rolf Renne; Taimour Y Langaee; Peter W Stacpoole; Margaret O James
Journal:  Drug Metab Dispos       Date:  2020-05-01       Impact factor: 3.922

2.  Sources of Interindividual Variability.

Authors:  Yvonne S Lin; Kenneth E Thummel; Brice D Thompson; Rheem A Totah; Christi W Cho
Journal:  Methods Mol Biol       Date:  2021

3.  A review of the alleged health hazards of monosodium glutamate.

Authors:  Anca Zanfirescu; Anca Ungurianu; Aristides M Tsatsakis; George M Nițulescu; Demetrios Kouretas; Aris Veskoukis; Dimitrios Tsoukalas; Ayse B Engin; Michael Aschner; Denisa Margină
Journal:  Compr Rev Food Sci Food Saf       Date:  2019-05-08       Impact factor: 12.811

Review 4.  Why We Need to Take a Closer Look at Genetic Contributions to CYP3A Activity.

Authors:  Qinglian Zhai; Maaike van der Lee; Teun van Gelder; Jesse J Swen
Journal:  Front Pharmacol       Date:  2022-06-16       Impact factor: 5.988

5.  The Promises of Quantitative Proteomics in Precision Medicine.

Authors:  Bhagwat Prasad; Marc Vrana; Aanchal Mehrotra; Katherine Johnson; Deepak Kumar Bhatt
Journal:  J Pharm Sci       Date:  2016-12-08       Impact factor: 3.534

6.  The role of hepatic cytochrome P450s in the cytotoxicity of sertraline.

Authors:  Si Chen; Qiangen Wu; Xilin Li; Dongying Li; Michelle Fan; Zhen Ren; Matthew Bryant; Nan Mei; Baitang Ning; Lei Guo
Journal:  Arch Toxicol       Date:  2020-05-05       Impact factor: 5.153

7.  Urinary microRNAs as potential biomarkers of pesticide exposure.

Authors:  Brittany A Weldon; Sara Pacheco Shubin; Marissa N Smith; Tomomi Workman; Alexander Artemenko; William C Griffith; Beti Thompson; Elaine M Faustman
Journal:  Toxicol Appl Pharmacol       Date:  2016-01-27       Impact factor: 4.219

Review 8.  Epigenetics and microRNAs in UGT1As.

Authors:  Cui-Lan Meng; Wei Zhao; Dan-Ni Zhong
Journal:  Hum Genomics       Date:  2021-05-25       Impact factor: 4.639

9.  Endogenous Protein Interactome of Human UDP-Glucuronosyltransferases Exposed by Untargeted Proteomics.

Authors:  Michèle Rouleau; Yannick Audet-Delage; Sylvie Desjardins; Mélanie Rouleau; Camille Girard-Bock; Chantal Guillemette
Journal:  Front Pharmacol       Date:  2017-02-03       Impact factor: 5.810

10.  Regulation of Pharmacogene Expression by microRNA in The Cancer Genome Atlas (TCGA) Research Network.

Authors:  Nayoung Han; Yun-Kyoung Song; Gilbert J Burckart; Eunhee Ji; In-Wha Kim; Jung Mi Oh
Journal:  Biomol Ther (Seoul)       Date:  2017-09-01       Impact factor: 4.634
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