Takehiko Doi1, Hiroyuki Shimada2, Hyuma Makizako2, Kota Tsutsumimoto2, Ryo Hotta2, Sho Nakakubo2, Takao Suzuki3. 1. Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan; Japan Society for the Promotion of Science, Tokyo, Japan; Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan. Electronic address: take-d@ncgg.go.jp. 2. Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan. 3. Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.
Abstract
OBJECTIVES: Mild cognitive impairment (MCI) may be a risk for disability, and co-occurrence of slow gait (SG) and MCI may increase this risk. DESIGN: Prospective study. SETTING: General community. PARTICIPANTS: The study included 3482 older adults (mean age: 71.4 years) without disability at baseline. MEASUREMENTS: We collected information on demographic variables, measured gait speed and cognitive function to diagnose MCI at baseline. During the follow-up period, the incident disability was monitored. Participants were divided into groups without MCI and SG (control), with SG without MCI (SG), without SG and with MCI in single (sMCI) or multiple (mMCI) domains, and with SG and MCI in single (sMCI + SG) and multiple (mMCI + SG) domains. RESULTS: During follow-up, 134 participants developed disability (mean follow-up: 29.4 months). The proportions of incident disability were higher in the MCI with SG, MCI, and SG groups, compared with the control group. SG [hazard ratio 2.27 (95% confidence interval: 1.38-3.73)], mMCI [2.56 (1.31-5.02)], sMCI + SG [2.46 (1.21-5.00)], and mMCI + SG [3.48 (1.79-6.76)] participants had risks for disability. CONCLUSIONS: Co-occurrence of SG and MCI in multiple domains has a higher risk of disability than each condition alone.
OBJECTIVES: Mild cognitive impairment (MCI) may be a risk for disability, and co-occurrence of slow gait (SG) and MCI may increase this risk. DESIGN: Prospective study. SETTING: General community. PARTICIPANTS: The study included 3482 older adults (mean age: 71.4 years) without disability at baseline. MEASUREMENTS: We collected information on demographic variables, measured gait speed and cognitive function to diagnose MCI at baseline. During the follow-up period, the incident disability was monitored. Participants were divided into groups without MCI and SG (control), with SG without MCI (SG), without SG and with MCI in single (sMCI) or multiple (mMCI) domains, and with SG and MCI in single (sMCI + SG) and multiple (mMCI + SG) domains. RESULTS: During follow-up, 134 participants developed disability (mean follow-up: 29.4 months). The proportions of incident disability were higher in the MCI with SG, MCI, and SG groups, compared with the control group. SG [hazard ratio 2.27 (95% confidence interval: 1.38-3.73)], mMCI [2.56 (1.31-5.02)], sMCI + SG [2.46 (1.21-5.00)], and mMCI + SG [3.48 (1.79-6.76)] participants had risks for disability. CONCLUSIONS: Co-occurrence of SG and MCI in multiple domains has a higher risk of disability than each condition alone.
Authors: Jessica M Jarvis; Brian Downer; Jacques Baillargeon; Mary Khetani; Kenneth J Ottenbacher; James E Graham Journal: Disabil Rehabil Date: 2018-01-30 Impact factor: 3.033
Authors: Magdalena Hagner-Derengowska; Krystian Kałużny; Wojciech Hagner; Anna Kałużna; Bartosz Kochański; Alina Borkowska; Jacek Budzyński Journal: Biomed Res Int Date: 2016-02-28 Impact factor: 3.411