Literature DB >> 26297977

The autotaxin-lysophosphatidic acid pathway in pathogenesis of rheumatoid arthritis.

Beatriz Orosa1, Samuel García1, Carmen Conde2.   

Abstract

Lysophosphatidic acid (LPA) is a phospholipid that is mainly produced by the hydrolysis of lysophosphatidylcholine (LPC) by lysophospholipase D, which is also called autotaxin (ATX). LPA interacts with specific G-protein coupled receptors and is involved in the regulation of cellular survival, proliferation, differentiation and motility. LPA also has roles in several pathological disorders, such as cancer and pulmonary, dermal and renal fibrosis. The involvement of the ATX-LPA pathway has recently been demonstrated in inflammatory responses and apoptosis of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis and during the development of experimental arthritis. This review summarises the current literature of the ATX-LPA pathway in rheumatoid arthritis.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Autotaxin; Experimental arthritis; Inflammatory response; Lysophosphatidic acid; Rheumatoid arthritis; fibroblast like; ibroblast‐like

Mesh：

Substances：

Year:  2015        PMID： 26297977     DOI： 10.1016/j.ejphar.2015.08.028

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  14 in total

1.  Autotaxin-Lysophosphatidic Acid Axis Blockade Improves Inflammation by Regulating Th17 Cell Differentiation in DSS-Induced Chronic Colitis Mice.

Authors:  Ya-Lan Dong; Xue-Yun Duan; Yu-Jin Liu; Heng Fan; Meng Xu; Qian-Yun Chen; Zhen Nan; Hui Wu; Shuang-Jiao Deng
Journal:  Inflammation       Date:  2019-10       Impact factor: 4.092

2.  Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity.

Authors:  Leona T Y Ho; Anja Osterwald; Iris Ruf; Daniel Hunziker; Patrizio Mattei; Pratap Challa; Robin Vann; Christoph Ullmer; Ponugoti Vasanth Rao
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2019-10-21       Impact factor: 5.187

3.  Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.

Authors:  Spencer B Jones; Lance A Pfeifer; Thomas J Bleisch; Thomas J Beauchamp; Jim D Durbin; V Joseph Klimkowski; Norman E Hughes; Christopher J Rito; Yen Dao; Joseph M Gruber; Hai Bui; Mark G Chambers; Srinivasan Chandrasekhar; Chaohua Lin; Denis J McCann; Daniel R Mudra; Jennifer L Oskins; Craig A Swearingen; Kannan Thirunavukkarasu; Bryan H Norman
Journal:  ACS Med Chem Lett       Date:  2016-08-02       Impact factor: 4.345

4.  Differential Effects of Inhibitor Combinations on Lysophosphatidic Acid-Mediated Chemokine Secretion in Unprimed and Tumor Necrosis Factor-α-Primed Synovial Fibroblasts.

Authors:  Weili Hui; Chenqi Zhao; Sylvain G Bourgoin
Journal:  Front Pharmacol       Date:  2017-11-21       Impact factor: 5.810

5.  Transient receptor potential canonical 5 channels plays an essential role in hepatic dyslipidemia associated with cholestasis.

Authors:  Khadija M Alawi; David Tandio; Jin Xu; Pratish Thakore; Georgia Papacleovoulou; Elizabeth S Fernandes; Cristina Legido-Quigley; Catherine Williamson; Susan D Brain
Journal:  Sci Rep       Date:  2017-05-24       Impact factor: 4.379

Review 6.  Chlorinated Phospholipids and Fatty Acids: (Patho)physiological Relevance, Potential Toxicity, and Analysis of Lipid Chlorohydrins.

Authors:  Jenny Schröter; Jürgen Schiller
Journal:  Oxid Med Cell Longev       Date:  2016-12-20       Impact factor: 6.543

7.  Increased aqueous autotaxin and lysophosphatidic acid levels are potential prognostic factors after trabeculectomy in different types of glaucoma.

Authors:  Nozomi Igarashi; Megumi Honjo; Makoto Kurano; Yutaka Yatomi; Koji Igarashi; Kuniyuki Kano; Junken Aoki; Makoto Aihara
Journal:  Sci Rep       Date:  2018-07-27       Impact factor: 4.379

Review 8.  Autotaxin in Pathophysiology and Pulmonary Fibrosis.

Authors:  Ioanna Ninou; Christiana Magkrioti; Vassilis Aidinis
Journal:  Front Med (Lausanne)       Date:  2018-06-13

9.  The incidence and risk of osteoporosis in patients with anxiety disorder: A Population-based retrospective cohort study.

Authors:  Chen Hong-Jhe; Kuo Chin-Yuan; Tu Ming-Shium; Wang Fu-Wei; Chen Ru-Yih; Hsueh Kuang-Chieh; Pan Hsiang-Ju; Chou Ming-Yueh; Chen Pan-Ming; Pan Chih-Chuan
Journal:  Medicine (Baltimore)       Date:  2016-09       Impact factor: 1.889

Review 10.  Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation.

Authors:  Matthew G K Benesch; Iain T K MacIntyre; Todd P W McMullen; David N Brindley
Journal:  Cancers (Basel)       Date:  2018-03-15       Impact factor: 6.639
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