Adriano Mota Loyola1, Sergio Vitorino Cardoso2, Paulo Rogério de Faria3, João Paulo Silva Servato4, Ana Lúcia Amaral Eisenberg5, Fernando Luiz Dias6, Selvam Thavaraj7, Carolina Cavalieri Gomes8, Ricardo Santiago Gomez9. 1. Associate Professor, Department of Oral and Maxillofacial Pathology, Federal University of Uberlândia, Uberlândia (MG), Brazil. Electronic address: Loyolaam@yahoo.com.br. 2. Adjunct Professor, Department of Oral and Maxillofacial Pathology, Federal University of Uberlândia, Uberlândia (MG), Brazil. 3. Adjunct Professor, Department of Morphology, Biomedical Science Institute, Federal University of Uberlândia, Uberlândia (MG), Brazil. 4. PhD Student, Department of Oral and Maxillofacial Pathology, Federal University of Uberlândia, Uberlândia (MG), Brazil. 5. Pathologist, Division of Pathology, Brazilian National Institute of Cancer, Rio de Janeiro (RJ), Brazil. 6. Head and Neck Surgeon, Division of Head and Neck Surgery, Brazilian National Institute of Cancer, Rio de Janeiro (RJ), Brazil. 7. Honorary Consultant in Oral/Head and Neck Pathology, Guy's & St Thomas' NHS Foundation Trust; Lecturer in Oral and Maxillofacial Pathology, King's College London Dental Institute, UK. 8. Adjunct Professor, Department of Pathology, Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil. 9. Titular Professor, Department of Oral Surgery and Pathology, Universidade Federal de Minas Gerais, Belo Horizonte (MG), Brazil.
Abstract
OBJECTIVE: To describe the clinicopathologic and immunohistochemical features of five cases of adenoid ameloblastoma. STUDY DESIGN: Clinicopathologic data were gathered from medical records and compared with those compiled from a systematic review. Slides were also immunohistochemically stained for Ki-67, p16, p53, and cytokeratins (7, 8, 14, 18, and 19). RESULTS: There were 3 males (60%) and 2 (40%) females. The mean age was 44 ± 10 years. Of the five adenoid ameloblastomas, 4 (80%) occurred in the posterior maxilla. Patients typically complained of asymptomatic swelling. All patients received surgical resection as primary therapy; 1 (20%) patient also received adjuvant radiotherapy. Recurrence was diagnosed in all patients. Immunohistochemically, the tumors stained focally positive for CK7, 8, 14, and 18 and diffusely positive for CK-19, p16, and p53. The mean Ki-67-positive cells were 72.4 ± 24.9 positive cells per high-power field (range 53-111). CONCLUSIONS: To our knowledge, this is the largest series of adenoid ameloblastoma reported in the literature. Our data suggest that this entity demonstrates aggressive behavior characterized by a high likelihood of recurrence.
OBJECTIVE: To describe the clinicopathologic and immunohistochemical features of five cases of adenoid ameloblastoma. STUDY DESIGN: Clinicopathologic data were gathered from medical records and compared with those compiled from a systematic review. Slides were also immunohistochemically stained for Ki-67, p16, p53, and cytokeratins (7, 8, 14, 18, and 19). RESULTS: There were 3 males (60%) and 2 (40%) females. The mean age was 44 ± 10 years. Of the five adenoid ameloblastomas, 4 (80%) occurred in the posterior maxilla. Patients typically complained of asymptomatic swelling. All patients received surgical resection as primary therapy; 1 (20%) patient also received adjuvant radiotherapy. Recurrence was diagnosed in all patients. Immunohistochemically, the tumors stained focally positive for CK7, 8, 14, and 18 and diffusely positive for CK-19, p16, and p53. The mean Ki-67-positive cells were 72.4 ± 24.9 positive cells per high-power field (range 53-111). CONCLUSIONS: To our knowledge, this is the largest series of adenoid ameloblastoma reported in the literature. Our data suggest that this entity demonstrates aggressive behavior characterized by a high likelihood of recurrence.
Authors: Liam Robinson; Chané Smit; Felipe Paiva Fonseca; Aline Corrêa Abrahão; Mário José Romañach; Syed Ali Khurram; Keith D Hunter; Paul M Speight; Willie F P van Heerden Journal: Head Neck Pathol Date: 2022-07-21
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