Literature DB >> 26297271

Investigating the Role of JAK/STAT Pathway on Dasatinib-Induced Apoptosis for CML Cell Model K562.

Ceyda Tunakan Dalgıç1, Burçin Tezcanlı Kaymaz2, Melda Cömert Özkan3, Ayşegül Dalmızrak2, Fahri Şahin3, Güray Saydam3.   

Abstract

We aimed to evaluate the cytotoxic and apoptotic effects of dasatinib (BMS-354825) on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on dasatinib-induced apoptosis. The results showed that dasatinib decreased proliferation and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT5A and STAT5B genes were significantly reduced in dasatinib-treated K562 cells. These data indicated that STAT inhibition by dasatinib might be therapeutic in JAK/STAT pathway-associated malignancies after confirmation with clinical studies.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Apoptosis; Chronic myeloid leukemia; Dasatinib; JAK/STAT pathway; STAT5

Mesh：

Substances：

Year:  2015        PMID： 26297271     DOI： 10.1016/j.clml.2015.02.012

Source DB:  PubMed          Journal:  Clin Lymphoma Myeloma Leuk        ISSN： 2152-2669


  10 in total

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7.  Thymoquinone Induces Downregulation of BCR-ABL/JAK/STAT Pathway and Apoptosis in K562 Leukemia Cells.

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10.  Thymoquinone Inhibits Growth of Acute Myeloid Leukemia Cells through Reversal SHP-1 and SOCS-3 Hypermethylation: In Vitro and In Silico Evaluation.

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Journal:  Pharmaceuticals (Basel)       Date:  2021-12-09
  10 in total

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