Preeti Singh-Hüsgen1, Thomas Meissner2, Mozhgan Bizhang3, Birgit Henrich4, Wolfgang H-M Raab5. 1. Department of Operative Dentistry, Periodontology and Endodontology, Heinrich Heine University, Moorenstrasse 5, Building No. 18.13, 40225, Düsseldorf, Germany. singh@med.uni-duesseldorf.de. 2. Department of General Paediatrics, University Children's Hospital, Heinrich Heine University, Moorenstrasse 5, Building No. 14, 40225, Düsseldorf, Germany. 3. Department of Operative and Preventive Dentistry, Witten/Herdecke University, Witten, Germany. 4. Institute for Medical Microbiology and Hospital Hygiene, Heinrich Heine University, Moorenstrasse 5, Building No. 22.21, 40225, Düsseldorf, Germany. 5. Department of Operative Dentistry, Periodontology and Endodontology, Heinrich Heine University, Moorenstrasse 5, Building No. 18.13, 40225, Düsseldorf, Germany.
Abstract
OBJECTIVE: The aim of this study was to investigate the oral parameters that influence the caries risk and risk of developing periodontal disease in children with phenylketonuria (PKU) and type 1 diabetes compared to healthy children. MATERIAL AND METHODS: Two hundred and thirty-eight children between the ages of 3 and 18 years were recruited in the PKU, diabetes and healthy group. The decayed, missing and filled surfaces (dmfs/DMFS) index, papillary bleeding index (PBI) and the Silness & Löe Index were assessed. Quantitative real-time polymerase chain reaction (PCR) was used for the detection of Streptococcus mutans (Sm), Lactobacillus casei (Lca), Lactobacillus species (Lac), Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg) and Tannerella forsythensis (Tf). RESULTS: A statistically significant difference in the dmfs index value was found between the three groups. The mean dmfs index value for the PKU children (4.18) was found to be relatively high. Comparing the three groups, diabetics showed statistically significant higher values for the Silness and Löe Index. Comparing the diabetics to just the healthy children, the diabetics revealed a small statistically significant difference in the PBI score. A statistically significant difference was found between Lac, Lca and Pg in the three groups. Counts of Lac were the lowest in the PKU children. The diabetics showed the highest counts of Lca but lowest for Pg. CONCLUSIONS: Comparing the three groups, children with PKU revealed a higher caries experience in their primary dentition. While the diabetic children showed a lower one in their primary dentition, they were found to possess a slightly higher risk of developing periodontal disease. CLINICAL RELEVANCE: It is proposed that both groups of child patients be encouraged to seek early dental advice and be incorporated in a meticulous prevention programme.
OBJECTIVE: The aim of this study was to investigate the oral parameters that influence the caries risk and risk of developing periodontal disease in children with phenylketonuria (PKU) and type 1 diabetes compared to healthy children. MATERIAL AND METHODS: Two hundred and thirty-eight children between the ages of 3 and 18 years were recruited in the PKU, diabetes and healthy group. The decayed, missing and filled surfaces (dmfs/DMFS) index, papillary bleeding index (PBI) and the Silness & Löe Index were assessed. Quantitative real-time polymerase chain reaction (PCR) was used for the detection of Streptococcus mutans (Sm), Lactobacillus casei (Lca), Lactobacillus species (Lac), Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg) and Tannerella forsythensis (Tf). RESULTS: A statistically significant difference in the dmfs index value was found between the three groups. The mean dmfs index value for the PKUchildren (4.18) was found to be relatively high. Comparing the three groups, diabetics showed statistically significant higher values for the Silness and Löe Index. Comparing the diabetics to just the healthy children, the diabetics revealed a small statistically significant difference in the PBI score. A statistically significant difference was found between Lac, Lca and Pg in the three groups. Counts of Lac were the lowest in the PKUchildren. The diabetics showed the highest counts of Lca but lowest for Pg. CONCLUSIONS: Comparing the three groups, children with PKU revealed a higher caries experience in their primary dentition. While the diabeticchildren showed a lower one in their primary dentition, they were found to possess a slightly higher risk of developing periodontal disease. CLINICAL RELEVANCE: It is proposed that both groups of childpatients be encouraged to seek early dental advice and be incorporated in a meticulous prevention programme.
Entities:
Keywords:
Caries; Microorganisms; Oral status; Phenylketonuria; Type 1 diabetes
Authors: Ivana Maria Saes Busato; Mônica Sommer Bittencourt; Maria Angela Naval Machado; Ana Maria Trindade Grégio; Luciana Reis Azevedo-Alanis Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Date: 2010-03
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