Literature DB >> 26296319

Chromatin, DNA structure and alternative splicing.

Nicolás Nieto Moreno1, Luciana E Giono1, Adrián E Cambindo Botto1, Manuel J Muñoz1, Alberto R Kornblihtt2.   

Abstract

Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well-studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA-interacting proteins and chromatin compaction. These may affect alternative splicing decisions by inducing pauses or decreasing elongation rate that change the time-window for splicing regulatory sequences to be recognized. Herein we discuss the evidence supporting the influence of template structural modifications on transcription and splicing, and provide insights about possible roles of non-B DNA conformations on the regulation of alternative splicing.
Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Keywords:  Alternative splicing; Chromatin structure; Non-B DNA; RNA polymerase II elongation

Mesh：

Substances：

Year:  2015        PMID： 26296319     DOI： 10.1016/j.febslet.2015.08.002

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


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