Literature DB >> 26296025

Exploiting In Situ Solid-State NMR for the Discovery of New Polymorphs during Crystallization Processes.

Colan E Hughes1, P Andrew Williams1, Thomas R Peskett1, Kenneth D M Harris1.   

Abstract

We report the discovery of new polymorphic forms of solids by exploiting a solid-state NMR technique that has been developed for in situ monitoring of the evolution of crystallization processes. The capability of the technique to reveal the existence of new polymorphic forms of molecular solids is illustrated by the discovery of two new polymorphs of methyldiphenylphosphine oxide and a new solid form of the 1,10-dihydroxydecane/urea system.

Entities:  

Keywords:  crystallization; in situ techniques; polymorphism; solid-state NMR

Year:  2012        PMID： 26296025     DOI： 10.1021/jz301252u

Source DB:  PubMed          Journal:  J Phys Chem Lett        ISSN： 1948-7185            Impact factor:   6.475


  1 in total

1.  "CLASSIC NMR": an in-situ NMR strategy for mapping the time-evolution of crystallization processes by combined liquid-state and solid-state measurements.

Authors:  Colan E Hughes; P Andrew Williams; Kenneth D M Harris
Journal:  Angew Chem Int Ed Engl       Date:  2014-07-07       Impact factor: 15.336
  1 in total

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