Literature DB >> 26295956

Revisiting the Function of CDK7 in Transcription by Virtue of a Recently Described TFIIH Kinase Inhibitor.

Frédéric Coin1, Jean-Marc Egly2.   

Abstract

In this issue of Molecular Cell, Nilson et al. (2015) took advantage of THZ1, a recently described covalent inhibitor of the TFIIH kinase CDK7, to further characterize the role of this enzyme in the early stages of transcription and postprocessing events. They unveiled an unexpected function of CDK7 in RNA polymerase II pausing and mRNA capping.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26295956     DOI： 10.1016/j.molcel.2015.08.006

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  10 in total

1.  The Covalent CDK7 Inhibitor THZ1 Potently Induces Apoptosis in Multiple Myeloma Cells In Vitro and In Vivo.

Authors:  Yu Zhang; Liang Zhou; Dipankar Bandyopadhyay; Kanika Sharma; Alexander Joseph Allen; Maciej Kmieciak; Steven Grant
Journal:  Clin Cancer Res       Date:  2019-07-29       Impact factor: 12.531

2.  Cdk7 Is Required for Activity-Dependent Neuronal Gene Expression, Long-Lasting Synaptic Plasticity and Long-Term Memory.

Authors:  Guiqin He; Xiangyu Yang; Guo Wang; Junxia Qi; Rui Mao; Zhengping Wu; Zikai Zhou
Journal:  Front Mol Neurosci       Date:  2017-11-07       Impact factor: 5.639

3.  Covalent CDK7 Inhibitor THZ1 Inhibits Myogenic Differentiation.

Authors:  Xinqi Ma; Xielan Kuang; Qing Xia; Zixin Huang; Yuting Fan; Jie Ning; Jiajie Wen; Han Zhang; Jianhua Yan; Qingjiong Zhang; Huangxuan Shen; Chongde Long
Journal:  J Cancer       Date:  2018-08-06       Impact factor: 4.207

4.  CDK7 inhibitor suppresses tumor progression through blocking the cell cycle at the G2/M phase and inhibiting transcriptional activity in cervical cancer.

Authors:  Shanshan Zhong; Yi Zhang; Xia Yin; Wen Di
Journal:  Onco Targets Ther       Date:  2019-03-22       Impact factor: 4.147

Review 5.  Transcriptional Silencing of MCL-1 Through Cyclin-Dependent Kinase Inhibition in Acute Myeloid Leukemia.

Authors:  Raoul Tibes; James M Bogenberger
Journal:  Front Oncol       Date:  2019-12-12       Impact factor: 6.244

6.  CDK7 Predicts Worse Outcome in Head and Neck Squamous-Cell Cancer.

Authors:  Tobias Jagomast; Christian Idel; Luise Klapper; Patrick Kuppler; Anne Offermann; Eva Dreyer; Karl-Ludwig Bruchhage; Julika Ribbat-Idel; Sven Perner
Journal:  Cancers (Basel)       Date:  2022-01-19       Impact factor: 6.639

7.  Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer.

Authors:  Maritere Uriostegui-Arcos; Rodrigo Aguayo-Ortiz; María Del Pilar Valencia-Morales; Erika Melchy-Pérez; Yvonne Rosenstein; Laura Dominguez; Mario Zurita
Journal:  Open Biol       Date:  2020-06-17       Impact factor: 6.411

Review 8.  Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases.

Authors:  Mario Zurita; Juan Manuel Murillo-Maldonado
Journal:  Int J Mol Sci       Date:  2020-01-17       Impact factor: 5.923

9.  Gene expression profile of THZ1-treated nasopharyngeal carcinoma cell lines indicates its involvement in the inhibition of the cell cycle.

Authors:  Lijuan Gao; Shuang Xia; Kunyi Zhang; Chengguang Lin; Xuyu He; Ying Zhang
Journal:  Transl Cancer Res       Date:  2021-01       Impact factor: 1.241

10.  Control of Expression of Key Cell Cycle Enzymes Drives Cell Line-Specific Functions of CDK7 in Human PDAC Cells.

Authors:  Lina Kolloch; Teresa Kreinest; Michael Meisterernst; Andrea Oeckinghaus
Journal:  Int J Mol Sci       Date:  2022-01-12       Impact factor: 5.923
  10 in total

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