Literature DB >> 2629585

Changes in calcium homeostasis during aging and Alzheimer's disease.

C Peterson1, R Ratan, M Shelanski, J Goldman.   

Abstract

Several observations indirectly suggest that intracellular calcium regulation may be altered by aging and Alzheimer's disease. Thus, calcium homeostasis was examined directly in skin fibroblasts from Alzheimer's patients and compared to cells from normal young and elderly controls. Alterations in both bound and free calcium were noted; cells from Alzheimer's donors have higher levels of bound calcium but lower concentrations of free intracellular calcium when compared to cells from young and normal aged donors. These changes in calcium homeostasis may be physiologically significant, since processes that require transient elevations of intracellular free calcium, such as cell spreading, decline in the Alzheimer's cells. In summary, cultured skin fibroblasts from normal aged and Alzheimer's patients demonstrate deficits in calcium homeostasis and other metabolic processes when compared to cells from young donors.

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Year:  1989        PMID： 2629585     DOI： 10.1111/j.1749-6632.1989.tb12515.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  7 in total

1.  Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner.

Authors:  J D Buxbaum; A A Ruefli; C A Parker; A M Cypess; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

2.  Cytosolic free [Ca2+] in mononuclear blood cells from demented patients and healthy controls.

Authors:  B Bondy; U Klages; F Müller-Spahn; C Hock
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  1994       Impact factor: 5.270

3.  Calcium currents in aged rat dorsal root ganglion neurones.

Authors:  P Kostyuk; N Pronchuk; A Savchenko; A Verkhratsky
Journal:  J Physiol       Date:  1993-02       Impact factor: 5.182

4.  Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease.

Authors:  R Etcheberrigaray; E Ito; K Oka; B Tofel-Grehl; G E Gibson; D L Alkon
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-01       Impact factor: 11.205

5.  Suppression of calcium-dependent membrane currents in human fibroblasts by replicative senescence and forced expression of a gene sequence encoding a putative calcium-binding protein.

Authors:  S Liu; R Thweatt; C K Lumpkin; S Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-15       Impact factor: 11.205

6.  Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis.

Authors:  Roman Uzhachenko; Kelli Boyd; Danyvid Olivares-Villagomez; Yueming Zhu; J Shawn Goodwin; Tanu Rana; Anil Shanker; Winston J T Tan; Tanya Bondar; Ruslan Medzhitov; Alla V Ivanova
Journal:  Aging (Albany NY)       Date:  2017-03-26       Impact factor: 5.682

7.  Identification of Cerebral Metal Ion Imbalance in the Brain of Aging Octodon degus.

Authors:  Nady Braidy; Anne Poljak; Chris Marjo; Helen Rutlidge; Anne Rich; Bat-Erdene Jugder; Tharusha Jayasena; Nibaldo C Inestrosa; Perminder S Sachdev
Journal:  Front Aging Neurosci       Date:  2017-03-29       Impact factor: 5.750
  7 in total

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