Literature DB >> 26294367

Empathy in individuals clinically at risk for psychosis: brain and behaviour.

Birgit Derntl1, Tanja Maria Michel2, Pamela Prempeh2, Volker Backes2, Andreas Finkelmeyer2, Frank Schneider2, Ute Habel2.   

Abstract

BACKGROUND: Empathy is a basic human ability, and patients with schizophrenia show dysfunctional empathic abilities on the behavioural and neural level. AIMS: These dysfunctions may precede the onset of illness; thus, it seems mandatory to examine the empathic abilities in individuals at clinical high risk for psychosis.
METHOD: Using functional magnetic resonance imaging, we measured 15 individuals at clinical high risk of psychosis (CHR group) and compared their empathy performance with 15 healthy volunteers and 15 patients with schizophrenia.
RESULTS: Behavioural data analysis indicated no significant deficit in the CHR group. Functional data analysis revealed hyperactivation in a frontotemporoparietal network including the amygdala in the CHR group compared with the other two groups.
CONCLUSIONS: Despite normal behavioural performance, the CHR group activated the neural empathy network differently and specifically showed hyperactivation in regions critical for emotion processing. This could suggest a compensatory mechanism reflecting emotional hypersensitivity or dysfunctional emotion regulation. Further investigations should clarify the role of these neural alterations for development and exacerbation of psychosis. © The Royal College of Psychiatrists 2015.

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Year:  2015        PMID: 26294367     DOI: 10.1192/bjp.bp.114.159004

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN: 0007-1250            Impact factor:   9.319


  7 in total

Review 1.  The roots of empathy: Through the lens of rodent models.

Authors:  K Z Meyza; I Ben-Ami Bartal; M H Monfils; J B Panksepp; E Knapska
Journal:  Neurosci Biobehav Rev       Date:  2016-11-04       Impact factor: 8.989

2.  Association Between Wisdom and Psychotic-Like Experiences in the General Population: A Cross-Sectional Study.

Authors:  Zhipeng Wu; Zhengqian Jiang; Zhipeng Wang; Yuqiao Ji; Feiwen Wang; Brendan Ross; Xiaoqi Sun; Zhening Liu; Yicheng Long
Journal:  Front Psychiatry       Date:  2022-04-18       Impact factor: 4.157

3.  Neural Correlates of Facial Emotion Recognition in Non-help-seeking University Students With Ultra-High Risk for Psychosis.

Authors:  Jiaojiao Hou; Simon Schmitt; Xudong Zhao; Jiayi Wang; Jianxing Chen; Ziyu Mao; Ansi Qi; Zheng Lu; Tilo Kircher; Yunbo Yang; Jingyu Shi
Journal:  Front Psychol       Date:  2022-06-09

4.  Pain empathy in schizophrenia: an fMRI study.

Authors:  William P Horan; Amy M Jimenez; Junghee Lee; Jonathan K Wynn; Naomi I Eisenberger; Michael F Green
Journal:  Soc Cogn Affect Neurosci       Date:  2016-01-08       Impact factor: 3.436

5.  A Short Empathy Paradigm to Assess Empathic Deficits in Schizophrenia.

Authors:  Foteini Peveretou; Sina Radke; Birgit Derntl; Ute Habel
Journal:  Behav Sci (Basel)       Date:  2020-01-24

6.  Acute oxytocin effects in inferring others' beliefs and social emotions in people at clinical high risk for psychosis.

Authors:  André Schmidt; Cathy Davies; Yannis Paloyelis; Nicholas Meyer; Andrea De Micheli; Valentina Ramella-Cravaro; Umberto Provenzani; Yuta Aoki; Grazia Rutigliano; Marco Cappucciati; Dominic Oliver; Silvia Murguia; Fernando Zelaya; Paul Allen; Sukhi Shergill; Paul Morrison; Steve Williams; David Taylor; Stefan Borgwardt; Hidenori Yamasue; Philip McGuire; Paolo Fusar-Poli
Journal:  Transl Psychiatry       Date:  2020-06-22       Impact factor: 7.989

Review 7.  Neural correlates of emotional processing in psychosis risk and onset - A systematic review and meta-analysis of fMRI studies.

Authors:  P B Lukow; A Kiemes; M J Kempton; F E Turkheimer; P McGuire; G Modinos
Journal:  Neurosci Biobehav Rev       Date:  2021-03-17       Impact factor: 8.989

  7 in total

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